Loss of muscle mass in women with premature ovarian insufficiency as compared with healthy controls

被引：5

作者：

Li, Saisai ^{[1
]}

Ma, Linjuan ^{[1
]}

Huang, Haiying ^{[2
]}

Lou, Zheng ^{[1
]}

Qi, Tongyun ^{[1
]}

Huang, Yizhou ^{[1
]}

Zou, Yu ^{[2
,4
]}

Zhou, Jianhong ^{[1
,3
]}

机构：

[1] Zhejiang Univ, Womens Hosp, Sch Med, Dept Gynecol, Hangzhou, Peoples R China

[2] Zhejiang Univ, Womens Hosp, Sch Med, Dept Radiol, Hangzhou, Peoples R China

[3] Zhejiang Univ, Womens Hosp, Sch Med, Dept Gynecol, 1st Xueshi Rd, Hangzhou 310006, Peoples R China

[4] Zhejiang Univ, Womens Hosp, Sch Med, Dept Radiol, 1st Xueshi Rd, Hangzhou 310006, Peoples R China

来源：

MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY | 2023年 / 30卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Chinese; Cross-sectional study; Dual-energy x-ray absorptiometry; Muscle mass parameters; Premature ovarian insufficiency; BONE-MINERAL DENSITY; ASIAN WORKING GROUP; BODY-COMPOSITION; TURNER-SYNDROME; STRENGTH; SARCOPENIA; PREVALENCE; AGE; MENOPAUSE; ESTRADIOL;

D O I：

10.1097/GME.0000000000002120

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

ObjectiveMenopausal transition has been known to be associated with the loss of muscle mass. However, muscle health in women with premature menopause, that is, premature ovarian insufficiency (POI), remains unclear. We aimed to investigate and compare muscle mass parameters and the prevalence of low muscle mass between patients with spontaneous POI and healthy controls.MethodsIn this cross-sectional study, 59 women with spontaneous POI and 57 premenopausal controls with normal ovarian function were enrolled at the Women's Hospital, Zhejiang University School of Medicine (Hangzhou, China) from June 17, 2020, to August 20, 2021. Muscle mass parameters were measured by dual-energy x-ray absorptiometry, and low muscle mass was diagnosed using the Asian Working Group for Sarcopenia criteria. In addition, participants provided their sociodemographic data, menstrual and reproductive history, lifestyle factors, and medical history. Multivariate linear regression analysis was conducted.ResultsMuscle mass parameters, including appendicular skeletal muscle mass (ASM), ASM/height(2), ASM/weight, ASM/body mass index, total skeletal muscle mass (TSM), and TSM/weight, were significantly lower in women with POI as compared with healthy controls (ASM: 14.62 +/- 2.08 vs 15.97 +/- 1.78, P < 0.001; ASM/height(2): 5.71 +/- 0.64 vs 6.15 +/- 0.62, P < 0.001; ASM/weight: 0.27 [0.25, 0.28] vs 0.28 [0.27, 0.29], P = 0.002; ASM/BMI: 0.68 +/- 0.07 vs 0.73 +/- 0.06, P = 0.001; TSM: 33.85 +/- 4.08 vs 36.43 +/- 3.56, P < 0.001; TSM/weight: 0.63 [0.59, 0.65] vs 0.64 [0.61, 0.67], P = 0.02). The prevalence of low muscle mass in POI patients was significantly higher than that in controls (32.20% vs 8.77%, chi(2) = 9.70, P = 0.002). Furthermore, multivariate linear regression analyses demonstrated that POI status was an independent risk factor for ASM (beta = -1.13; 95% CI, -1.62 to -0.65), ASM/height(2) (-0.35, -0.47 to -0.22), ASM/weight (-0.01, -0.02 to -0.009), ASM/BMI (-0.05, -0.07 to -0.02), TSM (-2.16, -3.14 to -1.17), and TSM/weight (-0.03, -0.04 to -0.02).ConclusionsWomen with POI exhibit significant loss of muscle mass as compared with healthy controls. Early diagnosis and long-term health management in POI patients are important.

引用

页码：122 / 127

页数：6