A novel superparamagnetic iron oxide nanoparticles-based SPECT/MRI dual-modality probe for tumor imaging

被引：3

作者：

Xi, Wenke ^{[1
,2
]}

Zhang, Ge ^{[2
,3
]}

Xue, Jingquan ^{[2
,4
]}

Li, Juan ^{[2
]}

Liu, Yu ^{[2
,3
,4
]}

Wang, Jianjun ^{[1
]}

Yang, Wenjiang ^{[2
,4
]}

机构：

[1] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China

[2] Chinese Acad Sci, Inst High Energy Phys, Beijing Engn Res Ctr Radiog Tech & Equipment, Beijing 100049, Peoples R China

[3] Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100049, Peoples R China

[4] Jinan Lab Appl Nucl Sci, Jinan 250131, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2023年 / 332卷 / 04期

基金：

北京市自然科学基金; 中国国家自然科学基金; 国家重点研发计划;

关键词：

SPECT/MRI; iron oxide nanoparticles; Dual-modality imaging; Tumor targeting; FUNCTIONALIZATION;

D O I：

10.1007/s10967-022-08741-z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Multimodal imaging has become a trend in the development of molecular imaging. For SPECT/MRI dual-modality imaging, we developed a SPECT/MRI dual-modality probe based on superparamagnetic iron oxide nanoparticles. RGDyk peptide and DTPA chelator were used to realize the functionalization of nanoparticles. Both SPECT imaging and T2-weighted MR imaging in vivo on 4T1 tumor-bearing mice showed targeting of the probe, demonstrating the potential of the SPECT/MRI dual-modality probe as a tool for tumor evaluation and diagnosis.

引用

页码：1237 / 1244

页数：8

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