Keratin intrinsic fluorescence as a mechanism for non-invasive monitoring of its glycation

被引：2

作者：

Muir, Rhona ^{[1
]}

Forbes, Shareen ^{[2
]}

Birch, David J. S. ^{[1
]}

Vyshemirsky, Vladislav ^{[3
]}

Rolinski, Olaf J. ^{[1
]}

机构：

[1] Univ Strathclyde, Scottish Univ Phys Alliance, Dept Phys, Photophys Grp, Glasgow G4 0NG, Scotland

[2] Univ Edinburgh, Queens Med Res Inst, BHF Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Scotland

[3] Univ Glasgow, Sch Math & Stat, Glasgow G12 8QQ, Scotland

来源：

METHODS AND APPLICATIONS IN FLUORESCENCE | 2023年 / 11卷 / 01期

关键词：

keratin; glucose; protein glycation; intrinsic fluorescence; time-resolved fluorescence spectroscopy; TRYPTOPHAN FLUORESCENCE; NONENZYMATIC GLYCATION; STRATUM-CORNEUM; HUMAN-SKIN; GLYCOSYLATION; PROTEINS; HAIR; AGE; SPECTROSCOPY; KYNURENINE;

D O I：

10.1088/2050-6120/aca507

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have studied the evolution of keratin intrinsic fluorescence as an indicator of its glycation. Steady-state and time-resolved fluorescence of free keratin and keratin-glucose samples were detected in PBS solutions in vitro. The changes in the fluorescence response demonstrate that the effect of glucose is manifest in the accelerated formation of fluorescent cross-links with an emission peak at 460 nm and formation of new cross-links with emission peaks at 525 nm and 575 nm. The fluorescence kinetics of these structures is studied and their potential application for the detection of long-term complications of diabetes discussed.

引用

页数：11

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