The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework

被引：0
|
作者：
Stalinskaya, Alena L. [1 ]
Dengis, Natalia A. [2 ]
Vlasenko, Vasily S. [2 ]
Kulakov, Ivan V. [1 ]
机构：
[1] Univ Tyumen, Sch Nat Sci, 15a Perekopskaya St, Tyumen 625003, Russia
[2] Omsk Agr Sci Ctr, 26 Koroleva Ave, Omsk 644012, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2024年 / 60卷 / 1-2期
基金：
俄罗斯科学基金会;
关键词：
4,5-dihydro-1H-pyrazoles; epoxybenzo[7,8]oxocino[4,3-b]pyridines; pyridyl chalcones; antitubercular activity; BENZOFURAN OXIDATIVE DEAROMATIZATION; BIOLOGICAL EVALUATION; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL ACTIVITY; POTENT ANTIOXIDANTS; ANTICANCER ACTIVITY; TETRACYCLIC CORE; DESIGN; INTEGRASTATINS; 3,5-DIACETYL-2,6-DIMETHYLPYRIDINE;
D O I：
10.1007/s10593-024-03291-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]-oxocino[4,3-b]pyridine with aromatic aldehydes. A subsequent cyclization with hydrazine hydrate in acetic acid led to the corresponding 4,5-dihydro-1H-pyrazole derivatives. An assessment of the resulting derivatives for antitubercular activity was carried out.
引用
收藏
页码：41 / 47
页数：7
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