We prove new results on the interplay between reduction numbers and the Castelnuovo-Mumford regularity of blowup algebras and blowup modules, the key basic tool being the operation of Ratliff-Rush closure. First, we answer in two particular cases a question of M. E. Rossi, D. T. Trung, and N. V. Trung about Rees algebras of ideals in two-dimensional Buchsbaum local rings, and we even ask whether one of such situations always holds. In another theorem we largely generalize a result of A. Mafi on ideals in two-dimensional Cohen-Macaulay local rings, by extending it to arbitrary dimension (and allowing for the setting relative to a Cohen-Macaulay module). We derive a number of applications, including a characterization of (polynomial) ideals of linear type, progress on the theory of generalized Ulrich ideals, and improvements of results by other authors.