General Ir-Catalyzed N-H Insertions of Diazomalonates into Aliphatic and Aromatic Amines

被引：5
作者：
Zhong, Zhuang [1 ]
Besnard, Celine [2 ]
Lacour, Jerome [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
[2] Univ Geneva, Lab Crystallog, Quai Ernest Ansermet 24, CH-1211 Geneva 4, Switzerland
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
CARBENE INSERTION; NITROGEN-HETEROCYCLES; BONDS; ACCESS; PLANAR;
D O I：
10.1021/acs.orglett.3c03929
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general N-H insertion reactivity of acceptor-acceptor diazo malonate reagents is reported using [Ir-(cod)-Cl](2) as catalyst. A large range of amines, primary and secondary, aliphatic and aromatic, is possible. Mild temperatures, perfect substrate/reactant stoichiometry, and good functional group compatibility render the process particularly attractive for the (late-stage) functionalization of amines.
引用
收藏
页码：983 / 987
页数：5
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