Dispensing of antineoplastic medications and their impact on the dispensing of anti-dementia drugs for adults aged ≥60 years: A cohort study

被引：0

作者：

Almeida, Osvaldo P. ^{[1
,4
]}

Etherton-Beer, Christopher ^{[1
]}

Sanfilippo, Frank ^{[2
]}

Preen, David B. ^{[2
]}

Page, Amy ^{[3
]}

机构：

[1] Univ Western Australia, Med Sch, Perth, Australia

[2] Univ Western Australia, Sch Populat & Global Hlth, Perth, Australia

[3] Univ Western Australia, Sch Allied Hlth, Perth, Australia

[4] Univ Western Australia, WA Ctr Hlth & Ageing M577, 35 Stirling Highway, Perth, WA 6009, Australia

来源：

MATURITAS | 2024年 / 180卷

关键词：

Dementia; Alzheimer's disease; cancer; Antineoplastic medications; Antidementia medications; Cholinesterase inhibitor; Memantine;

D O I：

10.1016/j.maturitas.2023.107888

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

History of cancer has been associated with decreased risk of dementia, but it is unclear if this is due to the use of antineoplastic medications. Participants were 442,795 adults aged >= 60 years, of whom 235,841 (53.26 %) were women. Those dispensed antineoplastic medications during 2012-2013 had lower odds of being dispensed an anti-dementia drug between 2015 and 2021 (age/sex-adjusted OR = 0.60, 95%CI = 0.55-0.66). The dispensing of antineoplastic medications was associated with an adjusted hazard ratio of 0.72 (95%CI = 0.65-0.80) of subsequent dispensing of an anti-dementia drug. Understanding the mechanisms that support this association may contribute to the introduction of novel approaches to dementia prevention.

引用

页数：3

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