Successful management of a colchicine overdose with plasmapheresis: a case report

被引：1

作者：

Toksul, Ibrahim Halil ^{[1
]}

Altundag, Ibrahim ^{[1
,4
]}

Cete, Riza ^{[1
]}

Kazzi, Ziad ^{[2
]}

Korkut, Semih ^{[3
]}

Sahin, Aynur ^{[1
]}

机构：

[1] Univ Hlth Sci, Basaksehir Cam & Sakura City Hosp, Dept Emergency Med, Med Toxicol Intens Care Unit, Istanbul, Turkiye

[2] Emory Univ, Sch Med, Dept Emergency Med, Sect Med Toxicol, Atlanta, GA USA

[3] Univ Hlth Sci, Basaksehir Cam & Sakura City Hosp, Dept Emergency Med, Istanbul, Turkiye

[4] Univ Hlth Sci, Basaksehir Cam & Sakura City Hosp, Dept Emergency Med, Med Toxicol Intens Care Unit, Basaksehir Olimpiyat Bulvari Yolu, TR-34480 Basaksehir Istanbul, Turkiye

来源：

TOXICOLOGY COMMUNICATIONS | 2023年 / 7卷 / 01期

关键词：

Colchicine overdose; deliberate self-harm; plasmapheresis; lymphopenia; case report;

D O I：

10.1080/24734306.2023.2286391

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

An overdose of colchicine can be lethal due to its narrow therapeutic index. We aimed to describe the successful management of a large intentional overdose with plasmapheresis therapy. A 32-year-old female presented to the Emergency Department with nausea, vomiting, and dizziness eight hours after intentionally ingesting 0.9 mg/kg colchicine in tablet form. She was treated with plasmapheresis and supportive therapy. The only abnormality in four days of observation was one-day transient lymphopenia (0.82 x 109/L).

引用

页数：4

共 20 条

[1] Successfully Treated Severe Colchicine Intoxication in an Adolescent [J].

Ari, Hatice Feray ;

Kirhan, Berna ;

Ari, Murat .

TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI, 2022, 20 (02) :102-105

[2] Colchicine: 1998 update [J].

Ben-Chetrit, E ;

Levy, M .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1998, 28 (01) :48-59

[3]

BISMUTH C, 1977, NOUV PRESSE MED, V6, P1625

[4]

BISMUTH C, 1986, J TOXICOL CLIN EXPER, V6, P33

[5] COLCHICINE - RECENT PHARMACOKINETIC AND CLINICAL PHARMACOLOGICAL DATA [J].

CHAPPEY, O ;

SCHERRMANN, JM .

REVUE DE MEDECINE INTERNE, 1995, 16 (10) :782-789

[6] Colchicine: an ancient drug with novel applications [J].

Dasgeb, B. ;

Kornreich, D. ;

McGuinn, K. ;

Okon, L. ;

Brownell, I. ;

Sackett, D. L. .

BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (02) :350-356

[7]

Dickinson Michael, 2009, Br J Haematol, V146, P465, DOI 10.1111/j.1365-2141.2009.07581.x

[8] Colchicine poisoning: the dark side of an ancient drug [J].

Finkelstein, Yaron ;

Aks, Steven E. ;

Hutson, Janine R. ;

Juurlink, David N. ;

Nguyen, Patricia ;

Dubnov-Raz, Gal ;

Pollak, Uri ;

Koren, Gideon ;

Bentur, Yedidia .

CLINICAL TOXICOLOGY, 2010, 48 (05) :407-414

[9] Update on colchicine and its mechanism of action. [J].

Molad Y. .

Current Rheumatology Reports, 2002, 4 (3) :252-256

[10] Fatal cardiovascular collapse following acute colchicine ingestion [J].

Mullins, ME ;

Carrico, EA ;

Horowitz, BZ .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2000, 38 (01) :51-54

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