LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels

被引:7
作者
Guo, Jia [1 ,2 ,3 ]
Xu, Zeyu [1 ,4 ]
Gunderson, Rachel C. [1 ]
Xu, Baohui [1 ,2 ]
Michie, Sara A. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
[3] Shanxi Med Univ, Ctr Hypertens Care, Hosp 1, Taiyuan 030001, Peoples R China
[4] Univ Cincinnati, Coll Med, Dept Med, Cincinnati, OH 45219 USA
基金
美国国家卫生研究院;
关键词
leukocyte function-associated antigen-1; intercellular adhesion molecule-1; lymphocytes; migration; lymphatics; ENDOTHELIUM IN-VITRO; REGULATORY T-CELLS; TRANSENDOTHELIAL MIGRATION; LANGERHANS CELLS; MANNOSE RECEPTOR; IMMUNE-RESPONSE; EFFERENT LYMPH; ICAM-1; CHEMOKINE; LFA-1;
D O I
10.3390/biom13081194
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lymphocyte function-associated antigen-1 (LFA-1) and its endothelial ligand intercellular adhesion molecule-1 (ICAM-1) are important for the migration of lymphocytes from blood vessels into lymph nodes. However, it is largely unknown whether these molecules mediate the homeostatic migration of lymphocytes from peripheral tissues into lymph nodes through lymphatic vessels. In this study, we find that, in naive mice, ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. In in vivo lymphocyte migration assays, memory CD4(+) T cells migrated to lymph nodes from peripheral tissues much more efficiently than from blood vessels, as compared to naive CD4(+) T cells. Moreover, ICAM-1 deficiency in host mice significantly inhibited the migration of adoptively transferred wild-type donor lymphocytes from peripheral tissues, but not from blood vessels, into lymph nodes. The migration of LFA-1-deficient donor lymphocytes from peripheral tissues into the lymph nodes of wild-type host mice was also significantly reduced as compared to wild-type donor lymphocytes. Furthermore, the number of memory T cells in lymph nodes was significantly reduced in the absence of ICAM-1 or LFA-1. Thus, our study extends the functions of the LFA-1/ICAM-1 adhesion pathway, indicating its novel role in controlling the homeostatic migration of lymphocytes from peripheral tissues into lymph nodes and maintaining memory T cellularity in lymph nodes.
引用
收藏
页数:18
相关论文
共 77 条
  • [1] Ando T., 2005, Lymphatic Research and Biology, V3, P105, DOI 10.1089/lrb.2005.3.105
  • [2] Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
    Arasa, Jorge
    Collado-Diaz, Victor
    Kritikos, Ioannis
    Medina-Sanchez, Jessica Danielly
    Friess, Mona Carina
    Sigmund, Elena Caroline
    Schineis, Philipp
    Hunter, Morgan Campbell
    Tacconi, Carlotta
    Paterson, Neil
    Nagasawa, Takashi
    Kiefer, Friedemann
    Makinen, Taija
    Detmar, Michael
    Moser, Markus
    Laemmermann, Tim
    Halin, Cornelia
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (07)
  • [3] Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node
    Bajenoff, Marc
    Egen, Jackson G.
    Qi, Hai
    Huan, Alex Y. C.
    Castellino, Flora
    Germain, Ronald N.
    [J]. TRENDS IN IMMUNOLOGY, 2007, 28 (08) : 346 - 352
  • [4] Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
    Berlin-Rufenach, C
    Otto, F
    Mathies, M
    Westermann, J
    Owen, MJ
    Hamann, A
    Hogg, N
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (09) : 1467 - 1478
  • [5] Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
    Boscacci, Remy T.
    Pfeiffer, Friederike
    Gollmer, Kathrin
    Checa Sevilla, Ana Isabel
    Maria Martin, Ana
    Soriano, Silvia Fernandez
    Natale, Daniela
    Henrickson, Sarah
    von Andrian, Ulrich H.
    Fukui, Yoshinori
    Mellado, Mario
    Deutsch, Urban
    Engelhardt, Britta
    Stein, Jens V.
    [J]. BLOOD, 2010, 116 (06) : 915 - 925
  • [6] Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
    Brinkman, C. Colin
    Iwami, Daiki
    Hritzo, Molly K.
    Xiong, Yanbao
    Ahmad, Sarwat
    Simon, Thomas
    Hippen, Keli L.
    Blazar, Bruce R.
    Bromberg, Jonathan S.
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [7] Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
    Bromley, SK
    Thomas, SY
    Luster, AD
    [J]. NATURE IMMUNOLOGY, 2005, 6 (09) : 895 - 901
  • [8] Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements during the Course of Inflammation
    Brown, Meghan N.
    Fintushel, Sarah R.
    Lee, Michael H.
    Jennrich, Silke
    Geherin, Skye A.
    Hay, John B.
    Butcher, Eugene C.
    Debes, Gudrun F.
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (08) : 4873 - 4882
  • [9] Lymphocyte homing and homeostasis
    Butcher, EC
    Picker, LJ
    [J]. SCIENCE, 1996, 272 (5258) : 60 - 66
  • [10] Chemokines in the systemic organization of immunity
    Campbell, DJ
    Kim, CH
    Butcher, EC
    [J]. IMMUNOLOGICAL REVIEWS, 2003, 195 : 58 - 71