Connecting the Dots: N6-Methyladenosine (m6A) Modification in Spermatogenesis

被引：1

作者：

Zhang, Mengya ^{[1
]}

Nie, Junyu ^{[1
]}

Chen, Yufei ^{[1
]}

Li, Xiaofeng ^{[2
]}

Chen, Hao ^{[1
]}

机构：

[1] Nantong Univ, Inst Reprod Med, Med Sch, Nantong 226000, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Dept Lab Med, Lianhua Rd 1120, Shenzhen 518000, Guangdong, Peoples R China

来源：

ADVANCED BIOLOGY | 2023年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

m(6)A modification; male reproduction; spermatogenesis; MESSENGER-RNA METHYLATION; METHYLTRANSFERASE METTL3 PROMOTES; NUCLEAR-RNA; N-6-METHYLADENOSINE; REVEALS; MEIOSIS; FTO; DEMETHYLATION; HELICASE; YTHDF2;

D O I：

10.1002/adbi.202300068

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

N6-methyladenosine (m(6)A) is the most common RNA modification found in eukaryotes and is involved in multiple biological processes, including neuronal development, tumorigenesis, and gametogenesis. It is well known that methylation-modifying enzymes (classified into writers, erasers, and readers) mediate catalysis, clearance, and recognition of m(6)A. Recent studies suggest that these genes may be associated with spermatogenesis. Numerous studies have revealed the m(6)A role during spermatogenesis. However, the expression patterns and relationships of these m(6)A enzymes during various stages of spermatogenesis remain unknown. In this review, it is aimed to provide an overview of m(6)A enzyme functions and elucidate their potential mechanisms and regulatory relationships at a specific phase during spermatogenesis, providing new insights into the m(6)A modification underlying the spermatogenesis process.

引用

页数：13

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