Identification of a luminescent platinum(II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells

被引：4
作者：
Wang, Yujing [1 ]
Wang, Shuping [2 ]
Wang, Qingqing [1 ]
Tang, Wanyu [1 ]
Lin, Li [3 ]
Zhang, Tao [3 ]
Hu, Meichun [3 ]
Wang, Xiaobo [1 ,4 ]
机构：
[1] Hubei Univ Sci & Technol, Xianning Med Coll, Sch Pharm, Xianning 437100, Peoples R China
[2] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China
[3] Hubei Univ Sci & Technol, Xianning Med Coll, Sch Basic Med Sci, Key Lab Environm Related Dis & One Hlth, Xianning 437100, Peoples R China
[4] Hubei Engn Res Ctr Tradit Chinese Med South Hubei, Xianning 437100, Peoples R China
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2023年 / 242卷
基金：
湖北省教育厅重点项目; 中国国家自然科学基金;
关键词：
Triple negative breast cancer (TNBC); Photodynamic therapy (PDT); BODIPY; Cytotoxicity; Apoptosis; DNA damage; BORON-DIPYRROMETHENE; TRANSCRIPTION FACTOR; ANTICANCER ACTIVITY; INDUCED APOPTOSIS; MITOCHONDRIA; PHOTOSENSITIZERS; STATISTICS; ACTIVATION; EFFICIENT; PROGRESS;
D O I：
10.1016/j.jinorgbio.2023.112160
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Triple-negative breast cancer (TNBC) is one of the most malignant breast tumors for its poor prognosis and high tumor recurrence. It is urgent to develop new strategy or effective agents to overcome resistance and improve therapeutic effectiveness. Boron-dipyrromethene (BODIPY) based photosensitizers possess exciting photo -physical features suitable for theranostic applications, namely, photodynamic therapy (PDT). We have designed a luminescent monofunctional platinum(II) complex with BODIPY derivative, namely I2BC-Pt, as novel high PDT agent against triple negative breast cancer (TNBC). The di-iodinated BODIPY complex I2BC-Pt showed excellent PDT effect against TNBC cells in green light (520 nm) giving IC50 values of 0.11-0.13 mu M in MDA-MB-231 and MDA-MB-468 cells. I2BC-Pt predominately aggregated in the mitochondria of MDA-MB-231 cells and emitted green fluorescence. Besides, the anticancer mechanism studies demonstrated that I2BC-Pt could help DNA repair through attenuating RAD51, FoxM1 and BRCA1/2, and induce p53-mediated apoptosis of TNBC cells. Taken together, I2BC-Pt could be potentially developed as a BODIPY-based photosensitizers for TNBC therapy.
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页数：11
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  • [1] Breast Cancer Statistics: Recent Trends
    Ahmad, Aamir
    [J]. BREAST CANCER METASTASIS AND DRUG RESISTANCE: CHALLENGES AND PROGRESS, 2ND EDITION, 2019, 1152 : 1 - 7
  • [2] Ali SM, 2002, INT J ONCOL, V21, P531
  • [3] The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
    Angus, Lindsay
    Smid, Marcel
    Wilting, Saskia M.
    van Riet, Job
    Van Hoeck, Arne
    Luan Nguyen
    Nik-Zainal, Serena
    Steenbruggen, Tessa G.
    Tjan-Heijnen, Vivianne C. G.
    Labots, Mariette
    van Riel, Johanna M. G. H.
    Bloemendal, Haiko J.
    Steeghs, Neeltje
    Lolkema, Martijn P.
    Voest, Emile E.
    van de Werken, Harmen J. G.
    Jager, Agnes
    Cuppen, Edwin
    Sleijfer, Stefan
    Martens, John W. M.
    [J]. NATURE GENETICS, 2019, 51 (10) : 1450 - +
  • [4] Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers
    Arora, Karan
    Herroon, Mackenzie
    Al-Afyouni, Malik H.
    Toupin, Nicholas P.
    Rohrabaugh, Thomas N., Jr.
    Loftus, Lauren M.
    Podgorski, Izabela
    Turro, Claudia
    Kodanko, Jeremy J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (43) : 14367 - 14380
  • [5] Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy
    Bassan, Elena
    Gualandi, Andrea
    Cozzi, Pier Giorgio
    Ceroni, Paola
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  • [6] Curcumin "Drug" Stabilized in Oxidovanadium(IV)-BODIPY Conjugates for Mitochondria-Targeted Photocytotoxicity
    Bhattacharyya, Utso
    Kumar, Brijesh
    Garai, Aditya
    Bhattacharyya, Arnab
    Kumar, Arun
    Banerjee, Samya
    Kondaiah, Paturu
    Chakravarty, Akhil R.
    [J]. INORGANIC CHEMISTRY, 2017, 56 (20) : 12457 - 12468
  • [7] Introducing the Tellurophene-Appended BODIPY: PDT Agent with Mass Cytometry Tracking Capabilities
    Campbell, Jacob W.
    Tung, Matthew T.
    Diaz-Rodriguez, Roberto M.
    Robertson, Katherine N.
    Beharry, Andrew A.
    Thompson, Alison
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (12): : 1925 - 1931
  • [8] Monitoring of the tumor response to nano-graphene oxide-mediated photothermal/photodynamic therapy by diffusion-weighted and BOLD MRI
    Cao, Jianbo
    An, Hengqing
    Huang, Xinglu
    Fu, Guifeng
    Zhuang, Rongqiang
    Zhu, Lei
    Xie, Jin
    Zhang, Fan
    [J]. NANOSCALE, 2016, 8 (19) : 10152 - 10159
  • [9] Photodynamic therapy for cancer
    Dolmans, DEJGJ
    Fukumura, D
    Jain, RK
    [J]. NATURE REVIEWS CANCER, 2003, 3 (05) : 380 - 387
  • [10] BODIPYs to the rescue: Potential applications in photodynamic inactivation
    Durantini, Andres M.
    Heredia, Daniel A.
    Durantini, Javier E.
    Durantini, Edgardo N.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 144 : 651 - 661
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