Elucidation of Physiological Functions of Vitamin K in the Brain and Development of New Derivatives for Neuroregeneration

被引:0
|
作者
Hirota, Yoshihisa [1 ,2 ]
机构
[1] Shibaura Inst Technol, Coll Syst Engn & Sci, Dept Biosci & Engn, Minuma Ku, 307 Fukasaku, Saitama 3378570, Japan
[2] Shibaura Inst Technol, Grad Sch Engn & Sci, Dept Syst Engn & Sci, Pharmaceut Sci Res,Minuma Ku, 307 Fukasaku, Saitama 3378570, Japan
来源
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2023年 / 143卷 / 03期
关键词
Vitamin K; neural differentiation; derivative development; L-type calcium channels; metabolic glutamate receptors; SELECTIVE NEURONAL DIFFERENTIATION; MENAQUINONE-4; VITAMIN-K-2; PHYLLOQUINONE VITAMIN-K-1;
D O I
10.1248/yakushi.22-00187
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Vitamin K plays an important role in blood coagulation and bone formation. However, apart from the liver and bone, the role of vitamin K in other tissues remains unknown. Previously, we have reported on high concentrations of vitamin K in the mouse brain and investigated vitamin K conversion in brain tissue. This led us to hypothesised the possibility of vitamin K contributing significantly towards maintenance and function of the cranial nervous system. In this review, we summarise the synthesis of novel vitamin K derivatives, their neuronal differentiation inducing activities and the induction mechanism. The findings from this study will provide insights into the physiological roles of vitamin K in the brain.
引用
收藏
页码:199 / 203
页数:5
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