KETOCONAZOLE-PAMAM DENDRIMER SUPRAMOLECULAR COMPLEX FOR PROLONGED DELIVERY BY IN VITRO AND IN VIVO STUDIES

被引：0
|
作者：
Kacso, Irina [1 ]
Baldea, Ioana [2 ]
Miclaus, Maria [1 ]
Mot, Augustin [1 ,3 ]
Moldovan, Remus [2 ]
Martin, Flavia [1 ]
机构：
[1] Natl Inst R&D Isotop & Mol Technol, 67-103 Donat Str, RO-400293 Cluj Napoca, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Dept Physiol, 1 Clinicilor Str, RO-400006 Cluj Napoca, Romania
[3] Fac Chem & Chem Engn, Dept Chem, 11 Arany Janos Str, RO-400028 Cluj Napoca, Romania
来源：
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2023年 / 68卷 / 04期
关键词：
Ketoconazole; PAMAM dendrimer; Drug-dendrimer complex; Solubility; Cell viability; Mouse ear sensitization test; DRUG; DISSOLUTION;
D O I：
10.24193/subbchem.2023.4.10
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The current study investigates the potential of the supramolecular complex between the antifungal agent Ketoconazole (KTZ) and PAMAM dendrimer G5 generation to be used as a topically applied antimycotic drug. The new drug-dendrimer formulation was confirmed by combining XRPD, FT-IR and DSC analytical techniques, and presents improved aqueous solubility and delayed in vitro release profile compare to pure KTZ. The biological assays data showed the biocompatibility of the supramolecular complex and improved delivery of the encapsulated KTZ into the superficial layers of skin and mucosa at the mycotic infections site, leading to a better outcome of the infection.
引用
收藏
页码：137 / 154
页数：18
相关论文
共 50 条
  • [1] Complex and in vitro release of methotrexate-PAMAM dendrimer
    Ye, L
    Jing, XZ
    Yang, H
    Su, JT
    Yun, LH
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2005, 26 (02): : 353 - 355
  • [2] Complex and in vitro release of methotrexate-PAMAM dendrimer
    Ye, Ling
    Jiang, Xiao-Zhou
    Yang, Hua
    Su, Jian-Ting
    Yun, Liu-Hong
    Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities, 2005, 26 (02): : 353 - 355
  • [3] Development of targeted gene delivery system based on liposome and PAMAM dendrimer functionalized with hyaluronic acid and TAT peptide: In vitro and in vivo studies
    Ebrahimian, Mahboubeh
    Hashemi, Maryam
    Farzadnia, Mahdi
    Zarei-Ghanavati, Siamak
    Malaekeh-Nikouei, Bizhan
    BIOTECHNOLOGY PROGRESS, 2022, 38 (05)
  • [4] A supramolecular thermosensitive gel of ketoconazole for ocular applications: In silico, in vitro, and ex vivo studies
    Chaudhari, Pinal
    Naik, Ranjitha
    Mallela, Lakshmi Sruthi
    Roy, Sanhita
    Birangal, Sumit
    Ghate, Vivek
    Kunhanna, Sarojini Balladka
    Lewis, Shaila A.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 613
  • [5] Arginine-Terminated Generation 4 PAMAM Dendrimer as an Effective Nanovector for Functional siRNA Delivery in Vitro and in Vivo
    Liu, Cheng
    Liu, Xiaoxuan
    Rocchi, Palma
    Qu, Fanqi
    Iovanna, Juan L.
    Peng, Ling
    BIOCONJUGATE CHEMISTRY, 2014, 25 (03) : 521 - 532
  • [6] Ewestigation of PAMAM dendrimer-MTX complex:: Formation and in vitro release
    Ye, L
    Yang, H
    He, ML
    Tang, YJ
    Chen, SL
    Yuan, Y
    Yun, LH
    ACTA POLYMERICA SINICA, 2006, (01): : 32 - 36
  • [7] Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation
    Yavuz, Burcin
    Pehlivan, Sibel Bozdag
    Bolu, Burcu Sumer
    Sanyal, Rana Nomak
    Vural, Imran
    Unlu, Nursen
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2016, 68 (08) : 1010 - 1020
  • [8] Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo
    Alibolandi, Mona
    Taghdisi, Seyed Mohammad
    Ramezani, Pouria
    Shamili, Fazileh Hosseini
    Farzad, Sara Amel
    Abnous, Khalil
    Ramezani, Mohammad
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 519 (1-2) : 352 - 364
  • [9] Co-delivery of doxorubicin and TRAIL plasmid by modified PAMAM dendrimer in colon cancer cells, in vitro and in vivo evaluation
    Pishavar, Elham
    Ramezani, Mohammad
    Hashemi, Maryam
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2019, 45 (12) : 1931 - 1939
  • [10] PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation
    Zhu, Saijie
    Hong, Minghuang
    Zhang, Lihong
    Tang, Guotao
    Jiang, Yanyan
    Pei, Yuanying
    PHARMACEUTICAL RESEARCH, 2010, 27 (01) : 161 - 174
12345