The Levels of Leptin, Cystatin C, Neuropilin-1 and Tau Protein in Relation to Dietary Habits in Patients with Alzheimer's Disease

被引：3

作者：

Bogdan, Sylwia ^{[1
]}

Puscion-Jakubik, Anna ^{[2
]}

Klimiuk, Katarzyna ^{[3
]}

Socha, Katarzyna ^{[2
]}

Kochanowicz, Jan ^{[4
]}

Gorodkiewicz, Ewa ^{[1
]}

机构：

[1] Univ Bialystok, Fac Chem, Bioanal Lab, Ciolkowskiego 1K, PL-15245 Bialystok, Poland

[2] Med Univ Bialystok, Fac Pharm, Div Lab Med, Dept Bromatol, Mickiewicza 2D St, PL-15222 Bialystok, Poland

[3] Podlasie Ctr Psychogeriatr, Swobodna 38 St, PL-15756 Bialystok, Poland

[4] Med Univ Bialystok, Dept Neurol, M Sklodowskiej Curie 24a St, PL-15276 Bialystok, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 21期

关键词：

Alzheimer's disease; diet; markers; ROC curve; SPR IMAGING BIOSENSOR; BETA-PROTEIN; BIOMARKERS; FUTURE; MARKER; BRAIN; SERUM;

D O I：

10.3390/jcm12216855

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) is the most common form of dementia in older people. Its prevalence is expected to increase, and therefore it poses a serious challenge to the healthcare system. The aim of the study was to assess the concentration of leptin, cystatin C, neuropilin-1 and tau protein, as well as the influence of dietary habits on these parameters, in a group of AD patients (n = 110) compared to 60 healthy people (n = 60). It has been shown that AD patients, compared to healthy people, are characterized by significantly higher median concentrations of leptin (9.97 vs. 3.08), cystatin c (1.53 vs. 0.56) and tau protein (8.46 vs. 4.19), but significantly lower median neuropilin-1 (69.94 vs. 167.28). Multiple regression analyses showed that leptin levels could be explained by dietary habits in 27%, cystatin C in 51%, neuropilin-1 in 41% and tau protein in 25% of cases. Modification of eating habits may contribute to improving the values of the discussed parameters.

引用

页数：14

共 46 条

[1] Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals [J].