Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging

Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design and implementation of the first dual modality handheld AO-OCT (HAOOCT) and scanning laser ophthalmoscope (SLO) probe to extend AO-OCT imaging to previously excluded patients. Simultaneous SLO imaging allows for tracking of imaging features for HAOOCT localization. Pilot experiments on stabilized and recumbent adults using HAOOCT, weighing only 665 grams, revealed the 3-D photoreceptor structure for the first time using a handheld AO-OCT/SLO device.