Dendritic spine dynamics in associative memory: A comprehensive review

被引：12

作者：

Guo, Hongling ^{[1
]}

Ali, Tahir ^{[1
]}

Que, Jianyu ^{[2
]}

Zhou, Yanmei ^{[3
]}

Bai, Yang ^{[3
]}

机构：

[1] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

[2] Xiamen Xianyue Hosp, Xiamen Mental Hlth Ctr, Fujian Clin Res Ctr Mental Disorders, Xiamen 361012, Peoples R China

[3] Shenzhen Bay Lab, Inst Neurol & Psychiat Disorders, Shenzhen 518132, Peoples R China

来源：

FASEB JOURNAL | 2023年 / 37卷 / 05期

关键词：

acquisition; associative memory; consolidation; reconsolidation; spine dynamics; RETRIEVAL-EXTINCTION PROCEDURE; ANTERIOR CINGULATE CORTEX; AMPA RECEPTOR TRAFFICKING; SYNAPTIC PLASTICITY; STRUCTURAL PLASTICITY; FEAR MEMORY; HIPPOCAMPAL DENDRITES; MORPHOLOGICAL-CHANGES; REMOTE MEMORY; SYNAPSES;

D O I：

10.1096/fj.202202166R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Associative learning and memory are fundamental behavioral processes through which organisms adapt to complex environments. Associative memory involves long-lasting changes in synaptic plasticity. Dendritic spines are tiny protrusions from the dendritic shaft of principal neurons, providing the structural basis for synaptic plasticity and brain networks in response to external stimuli. Mounting evidence indicates that dendritic spine dynamics are crucial in different associative memory phases, including acquisition, consolidation, and reconsolidation. Causally bridging dendritic spine dynamics and associative memory is still limited by the suitable tools to measure and control spine dynamics in vivo under behaviorally relevant conditions. Here, we review data providing evidence for the remodeling of dendritic spines during associative memory processing and outline open questions.

引用

页数：14

共 142 条

[1] Dendritic spine density and EphrinB2 levels of hippocampal and anterior cingulate cortex neurons increase sequentially during formation of recent and remote fear memory in the mouse [J].