Electrochemical sensor for fluorouracil determination using screen-printed cobalt sulfide-graphene composite electrode

被引：5
|
作者：
Khoshroo, Alireza [1 ]
Hosseinzadeh, Laleh [2 ]
Ehrlich, Hermann [3 ,4 ]
Ahmadi, Farhad [5 ]
Rahimi-Nasrabadi, Mehdi [3 ,6 ]
机构：
[1] Hamadan Univ Med Sci, Nutr Hlth Res Ctr, Hamadan, Iran
[2] Islamic Azad Univ, Dept Chem, Dehloran Branch, Dehloran, Iran
[3] TU Bergakademie Freiberg, Inst Elect & Sensor Mat, D-09599 Freiberg, Germany
[4] Adam Mickiewicz Univ, Ctr Adv Technol, 61614, Poznan, Poland
[5] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran
[6] Univ Tehran, Ctr Excellence Electrochem, Sch Chem, Tehran, Iran
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS | 2023年 / 34卷 / 06期
关键词：
CARBON-PASTE ELECTRODE; ANTICANCER DRUG 5-FLUOROURACIL; GOLD NANOPARTICLES; STRUCTURAL-CHARACTERIZATION; NANOCOMPOSITE; CAPECITABINE; PLATFORM;
D O I：
10.1007/s10854-023-09889-4
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The measurement of 5-fluorouracil in body fluids is important due to the side effects of this drug that causes neurotoxicity in humans. In this direct, an electrochemical sensor based on the screen-printed electrode (SPE) with cobalt sulfide-graphene nanocomposite (CosGr) was developed for the determination of 5-fluorouracil. The CosGr-SPE presents a wide linear range from 0.1 mu M to 600 mu M with LOD of 0.04 mu M. The real sample analysis results confirm that the CosGr/SPE is appropriate for detection of fluorouracil in real samples. This developed electrochemical sensor offers acceptable reproducibility, repeatability, sensitivity and low limit of detection toward 5-fluorouracil.
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收藏
页数：9
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