The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer

被引：30

作者：

Schepisi, Giuseppe ^{[1
]}

Gianni, Caterina ^{[1
]}

Palleschi, Michela ^{[1
]}

Bleve, Sara ^{[1
]}

Casadei, Chiara ^{[1
]}

Lolli, Cristian ^{[1
]}

Ridolfi, Laura ^{[1
]}

Martinelli, Giovanni ^{[1
]}

De Giorgi, Ugo ^{[1
]}

机构：

[1] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, I-47014 Meldola, Italy

来源：

CANCERS | 2023年 / 15卷 / 05期

关键词：

chimeric antigen receptor (CAR); macrophages; T cells; immunotherapy; breast cancer; TUMOR-ASSOCIATED MACROPHAGES; C-MET ANTIBODY; MONOCLONAL-ANTIBODY; SOLID TUMORS; BISPECIFIC ANTIBODY; ANTITUMOR EFFICACY; AXL KINASE; EXPRESSION; GROWTH; MESOTHELIN;

D O I：

10.3390/cancers15051597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary To date, different therapeutic strategies, including immunotherapies, have been shown to prolong survival in breast cancer patients, representing one of the most common malignancies. Our article deals with chimeric antigen receptor-based immunotherapy in breast cancer. Breast cancer represents one of the most common tumor histologies. To date, based on the specific histotype, different therapeutic strategies, including immunotherapies, capable of prolonging survival are used. More recently, the astonishing results that were obtained from CAR-T cell therapy in haematological neoplasms led to the application of this new therapeutic strategy in solid tumors as well. Our article will deal with chimeric antigen receptor-based immunotherapy (CAR-T cell and CAR-M therapy) in breast cancer.

引用

页数：21

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