Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study

被引：3

作者：

Nakazawa, Taro ^{[1
,2
]}

Ohara, Tomoyuki ^{[1
,2
]}

Hirabayashi, Naoki ^{[2
,3
]}

Furuta, Yoshihiko ^{[2
,4
]}

Hata, Jun ^{[2
,4
,5
]}

Shibata, Mao ^{[2
,3
,5
]}

Honda, Takanori ^{[2
]}

Kitazono, Takanari ^{[4
,5
]}

Nakao, Tomohiro ^{[1
]}

Ninomiya, Toshiharu ^{[2
,5
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, Fukuoka, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Ctr Cohort Studies, Fukuoka, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2023年 / 77卷 / 06期

关键词：

Alzheimer disease; cerebral small vessel diseases; dementia; leukoencephalopathies; Vascular; STRUCTURAL NETWORK EFFICIENCY; RISK-FACTORS; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; FOLLOW-UP; PREDICT; HYPERINTENSITIES; PEOPLE; VOLUME;

D O I：

10.1111/pcn.13533

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population.Methods: One thousand one hundred fifty-eight Japanese dementia-free community-residents aged >= 65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total brain atrophy, defined as the TBV-to-ICV ratio (TBV/ICV), and dementia-related regional brain atrophy defined based on our previous report were calculated. The association between dementia risk and the combined measures of WMLV/ICV and either total brain atrophy or the number of atrophied regions was also tested.Results: During the follow-up, 113 participants developed dementia. The risks of dementia increased significantly with higher WMLV/ICV levels. In addition, dementia risk increased additively both in participants with higher WMLV/ICV levels and lower TBV/ICV levels and in those with higher WMLV/ ICV levels and a higher number of dementia-related brain regional atrophy.Conclusion: The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.

引用

页码：330 / 337

页数：8

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