Untargeted metabolite profiling of serum in rats exposed to pyrraline

被引：2

作者：

Hu, Chuanqin ^{[1
]}

Wang, Jiahui ^{[1
]}

Qi, Fangyuan ^{[1
]}

Liu, Yingli ^{[1
]}

Zhao, Fen ^{[1
]}

Wang, Jing ^{[1
]}

Sun, Baoguo ^{[1
]}

机构：

[1] Beijing Technol & Business Univ BTBU, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing Engn & Technol Res Ctr Food Addit, Beijing Lab Food Qual & Safety,Key Lab Cleaner Pro, 11 Fucheng Rd, Beijing 100048, Peoples R China

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2023年 / 32卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Mass spectrometry (MS); Food safety; Metabolomic; Untargeted metabolite profiling; Pyrraline; MAILLARD REACTION; ADIPOSE-TISSUE; METABOLOMICS; HEPATOTOXICITY; PRODUCTS; AGES; MICE;

D O I：

10.1007/s10068-023-01256-7

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.

引用

收藏

页码：1541 / 1549

页数：9

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