Impact of coronavirus disease 2019 on lung cancer patients: A meta-analysis

被引:7
作者
Wang, Linlin [1 ]
Wang, Ye [2 ]
Cheng, Xianbin [3 ]
Li, Xingzhao [1 ]
Li, Jun [4 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Ultrasound, Changchun 130033, Jilin, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Pediat, Changchun 130033, Jilin, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Dept Gastrointestinal Colorectal & Anal Surg, Changchun 130033, Jilin, Peoples R China
[4] Jilin Univ, China Japan Union Hosp, Dept Hematol & Oncol, Changchun 130033, Jilin, Peoples R China
来源
TRANSLATIONAL ONCOLOGY | 2023年 / 28卷
关键词
SARS-CoV-2; COVID-19; Meta-analysis; Lung cancer; CLINICAL CHARACTERISTICS; MORTALITY-RATE; RISK-FACTORS; COVID-19; DIAGNOSIS; OUTCOMES; MULTICENTER; SARS-COV-2; CHINA;
D O I
10.1016/j.tranon.2022.101605
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The coronavirus disease 2019 (COVID-19) pandemic poses a great challenge to the treatment of lung cancer patients. Materials and methods: The PubMed, Embase, and Web of Science databases were searched for studies published before March 15, 2022, and Stata 14.0 software was used to perform a meta-analysis with a random-effects model. The odds ratio (OR) along with the corresponding 95% confidence interval (CI) was reported. Results: Our meta-analysis included 80 articles with 318,352 patients involved. The proportion of lung cancer patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was 2.4% (95% CI: 0.02-0.03) prior to the Omicron variant outbreak. Among COVID-19 patients, those with lung cancer showed a higher mortality rate than those with other types of malignant solid tumors (OR = 1.82, 95% CI: 1.61-2.06) and non-cancer patients (OR = 4.67, 95% CI: 3.61-6.05); however, no significant difference was observed in the mortality rate between patients with lung cancer and those with hematologic malignancies (OR = 1.07, 95% CI: 0.85-1.33). SARS-CoV-2 infection significantly increased the mortality rate in lung cancer patients (OR = 8.94, 95% CI: 6.50-12.31). By contrast, the all-cause mortality rate in lung cancer patients (OR = 1.04, 95% CI: 0.69-1.57) and the proportion of patients diagnosed with advanced lung cancer (OR = 1.04, 95% CI: 0.85-1.27) did not significantly change before and after the pandemic. Conclusions: More attention should be paid on improving the health of lung cancer patients during the COVID-19 pandemic.
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页数:13
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