SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis

被引：10

作者：

van Kempen, Zoe L. E. ^{[1
]}

Stalman, Eileen W. ^{[1
]}

Steenhuis, Maurice ^{[2
,3
]}

Kummer, Laura Y. L. ^{[1
,2
]}

van Dam, Koos P. J. ^{[1
]}

Wilbrink, Maarten F. ^{[1
]}

ten Brinke, Anja ^{[2
,4
]}

van Ham, S. Marieke ^{[2
,5
]}

Kuijpers, Taco ^{[6
]}

Rispens, Theo ^{[2
]}

Eftimov, Filip ^{[1
]}

Wieske, Luuk ^{[1
,7
]}

Killestein, Joep ^{[1
]}

机构：

[1] Amsterdam UMC, Locat AMC, Amsterdam Neurosci, Neurol, Amsterdam, Netherlands

[2] Amsterdam UMC, Locat VUMC, Sanquin Res & Landsteiner Lab, Immunopathol, Amsterdam, Netherlands

[3] Sanquin Diagnost Serv, Biol Lab, Amsterdam, Netherlands

[4] Amsterdam Inst Infect & Immun, Amsterdam, Netherlands

[5] Amsterdam UMC, Swammerdam Insitute Life Sci, Amsterdam, Netherlands

[6] Amsterdam UMC, Locat AMC, Pediat Immunol Rheumatol & Infect Dis, Amsterdam, Netherlands

[7] St Antonius Hosp, Clin Neurophysiol, Nieuwegein, Netherlands

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2023年 / 94卷 / 04期

关键词：

MULTIPLE SCLEROSIS; COVID-19;

D O I：

10.1136/jnnp-2022-330100

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundIt is unclear which patients with multiple sclerosis (MS) are most susceptible for omicron breakthrough infections. MethodsWe assessed omicron breakthrough infections in vaccinated patients with MS with and without disease-modifying therapies enrolled in an ongoing large prospective study. We longitudinally studied humoral responses after primary and booster vaccinations and breakthrough infections. ResultsOmicron breakthrough infections were reported in 110/312 (36%) patients with MS, and in 105/110 (96%) infections were mild. Omicron breakthrough infections occurred more frequently in patients treated with anti-CD20 therapies and sphingosine-1 phosphate receptor (S1PR) modulators, patients with impaired humoral responses after primary immunisation (regardless of treatment) and patients without prior SARS-CoV-2 infections. After infection, antibody titres increased in patients on S1PR modulator treatment while anti-CD20 treated patients did not show an increase. ConclusionsSARS-COV-2 omicron breakthrough infections are more prevalent in patients with MS on anti-CD20 therapies and S1PR modulators compared with other patients with MS, which correlated with decreased humoral responses after vaccination. Humoral responses after infection were higher in S1PR modulator-treated patients in comparison to patients on anti-CD20 therapies, suggesting that immunological protection from contracting infection or repeated exposures may differ between these therapies.

引用

页码：280 / 283

页数：4

共 12 条

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