Plant-derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

被引：3
作者：
Lu, Lan [1 ]
Wang, Jingya [1 ]
Wang, Chongrui [2 ]
Zhu, Jie [1 ]
Wang, Hongping [3 ]
Liao, Li [1 ]
Zhao, Yuting [1 ]
Wang, Xiaobo [4 ]
Yang, Chen [1 ]
He, Zhengyou [1 ,7 ]
Li, Mingxing [5 ,6 ,8 ]
机构：
[1] Chengdu Univ, Key Lab Med & Edible Plants Resources Dev, Sichuan Educ Dept, Sichuan Ind Inst Antibiot,Sch Pharm, Chengdu, Sichuan, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Fac Tradit Chinese Med, Jinan, Shandong, Peoples R China
[3] Sichuan Testing Ctr Med Devices, Sichuan Inst Drug Control, Safety Evaluat Ctr, Chengdu, Sichuan, Peoples R China
[4] Langzhong Peoples Hosp, Dept Hepatobiliary Surg, Langzhong, Sichuan, Peoples R China
[5] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China
[6] Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou, Sichuan, Peoples R China
[7] Chengdu Univ, Key Lab Med & Edible Plants Resources Dev, Sichuan Educ Dept, Sichuan Ind Inst Antibiot,Sch Pharm, Chengdu 610000, Sichuan, Peoples R China
[8] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Sichuan, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2024年 / 38卷 / 02期
基金：
中国国家自然科学基金;
关键词：
antivirulence strategy; natural products; virulence arresting drugs; virulence factors; RESISTANT ESCHERICHIA-COLI; BIOFILM FORMATION; ALPHA-TOXIN; ANTIBACTERIAL; SECRETION; ADHESION; SYSTEMS; ALLICIN; TRANSPORTER; MECHANISMS;
D O I：
10.1002/ptr.8072
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires global action. The occurrence of bacterial pathogens with multi-drug resistance appeals to exploring alternative therapeutic strategies. Antivirulence treatment has been a positive substitute in seeking to circumvent AMR, which aims to target virulence factors directly to combat bacterial infections. Accumulated evidence suggests that plant-derived natural products, which have been utilized to treat infectious diseases for centuries, can be abundant sources for screening potential virulence-arresting drugs (VADs) to develop advanced therapeutics for infectious diseases. This review sums up some virulence factors and their actions in various species of bacteria, as well as recent advances pertaining to plant-derived natural products as VAD candidates. Furthermore, we also discuss natural VAD-related clinical trials and patents, the perspective of VAD-based advanced therapeutics for infectious diseases and critical challenges hampering clinical use of VADs, and genomics-guided identification for VAD therapeutic. These newly discovered natural VADs will be encouraging and optimistic candidates that may sustainably combat AMR. Plant-derived virulence arresting drugs as novel antimicrobial agents.image
引用
收藏
页码：727 / 754
页数：28
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