Emerging principles of primary cilia dynamics in controlling tissue organization and function

被引：19

作者：

Gopalakrishnan, Jay ^{[1
]}

Feistel, Kerstin ^{[2
]}

Friedrich, Benjamin M. ^{[3
]}

Grapin-Botton, Anne ^{[3
,4
,5
,6
]}

Jurisch-Yaksi, Nathalie ^{[7
]}

Mass, Elvira ^{[8
]}

Mick, David U. ^{[9
]}

Mueller, Roman-Ulrich ^{[10
,11
,12
,13
]}

May-Simera, Helen ^{[14
]}

Schermer, Bernhard ^{[10
,11
,12
,13
]}

Schmidts, Miriam ^{[15
,16
]}

Walentek, Peter ^{[16
,17
]}

Wachten, Dagmar ^{[18
]}

机构：

[1] Heinrich Heine Univ, Univ Klinikum Dusseldorf, Inst Human Genet, Dusseldorf, Germany

[2] Univ Hohenheim, Inst Biol, Dept Zool, Stuttgart, Germany

[3] Tech Univ Dresden, Cluster Excellence Phys Life, Dresden, Germany

[4] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany

[5] Univ Hosp Carl Gustav Carus, TU Dresden, Helmholtz Ctr Munich, Paul Langerhans Inst Dresden, Dresden, Germany

[6] Tech Univ Dresden, Fac Med, Dresden, Germany

[7] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway

[8] Univ Bonn, Life & Med Sci Inst, Dev Biol Immune Syst, Bonn, Germany

[9] Saarland Sch Med, Ctr Human & Mol Biol ZHMB, Ctr Mol Signaling PZMS, Homburg, Germany

[10] Univ Cologne, Dept Internal Med 2, Cologne, Germany

[11] Univ Cologne, Fac Med, Ctr Mol Med Cologne, Cologne, Germany

[12] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[13] Univ Cologne, Fac Med, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany

[14] Univ Hosp Freiburg, Ctr Pediat & Adolescent Med, Pediat Genet Div, Freiburg, Germany

[15] Johannes Gutenberg Univ Mainz, Inst Mol Physiol, Mainz, Germany

[16] Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Freiburg, Germany

[17] Univ Freiburg, Med Ctr, Renal Div, Internal Med 4, Freiburg, Germany

[18] Univ Bonn, Inst Innate Immun, Med Fac, Biophys Imaging, Bonn, Germany

来源：

EMBO JOURNAL | 2023年 / 42卷 / 21期

基金：

欧洲研究理事会;

关键词：

cilia dynamics; ciliary signaling; cilium disassembly; primary cilia; tissue organization; PROTEIN-COUPLED RECEPTORS; BARDET-BIEDL-SYNDROME; RETINAL-PIGMENT EPITHELIUM; LEFT-RIGHT ASYMMETRY; PLANAR CELL POLARITY; IFT-A COMPLEX; INTRAFLAGELLAR TRANSPORT; EXTRACELLULAR VESICLES; LEFTWARD FLOW; PROTEOMIC ANALYSIS;

D O I：

10.15252/embj.2023113891

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function. This review summarizes recent insights into the dynamic changes in primary cilia composition, signaling, and assembly and disassembly during tissue organization.image

引用

页数：29

共 414 条

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