Weight Change and Neuropsychiatric Symptoms in Alzheimer's Disease and Frontotemporal Dementia: Associations with Cognitive Decline

被引：3
作者：
Morrow, Christopher B. [1 ]
Leoutsakos, Jeannie [1 ]
Yan, Haijuan [1 ]
Onyike, Chiadi [1 ]
Kamath, Vidyulata [1 ]
机构：
[1] Johns Hopkins Sch Med, Psychiat & Behav Sci, Baltimore, MD USA
来源：
JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期
关键词：
Alzheimer's disease; body mass index; cognition; cognitive decline; frontotemporal dementia; neuropsychiatric; symptoms; weight changes; DATA SET UDS; EATING BEHAVIOR; NUTRITION; IMPAIRMENT; CENTERS; PLASMA; BRAIN; SCALE; RISK; AGE;
D O I：
10.3233/ADR-230034
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer's disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.
引用
收藏
页码：767 / 774
页数：8
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