Rituximab for treatment of pachymeningitis in granulomatosis with polyangiitis

被引：0

作者：

Patankar, Aditi ^{[1
]}

Yadav, Sandeep ^{[1
]}

Balakrishnan, Canchi ^{[1
]}

Baliga, Sahana ^{[1
]}

机构：

[1] PD Hinduja Natl Hosp & Med Res Ctr, Rheumatol, Mumbai, Maharashtra, India

来源：

BMJ CASE REPORTS | 2023年 / 16卷 / 07期

关键词：

Cryptococcosis; Vasculitis; Biological agents; NERVOUS-SYSTEM INVOLVEMENT; ANCA-ASSOCIATED VASCULITIS; HYPERTROPHIC PACHYMENINGITIS; WEGENERS-GRANULOMATOSIS; MANIFESTATION; THERAPY;

D O I：

10.1136/bcr-2022-253835

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pachymeningitis is a rare manifestation of granulomatosis with polyangiitis (GPA), and there is a paucity of literature regarding the efficiency of rituximab (RTX) in such cases. We present a woman in her early 50s with GPA who initially responded adequately to conventional therapy. However, the treatment course was complicated by pulmonary cryptococcosis. The patient later developed non-infectious pachymeningitis, which failed to respond to steroids and methotrexate. However, using RTX upfront led to good clinical response and radiological resolution.

引用

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