Free Carboxylic Acids: The Trend of Radical Decarboxylative Functionalization

被引：48
|
作者：
Li, Liubo [1 ,2 ]
Yao, Yan [1 ,2 ,3 ]
Fu, Niankai [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Funct Inst Chem, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 21期
基金：
中国国家自然科学基金;
关键词：
decarboxylative functionalization; electrochemistry; electrophotochemistry; ligand-to-metal charge transfer (LMCT); photoredox; ALPHA-AMINO-ACIDS; TRANSITION-METAL; OXIDATIVE DECARBOXYLATION; ELECTROCHEMICAL OXIDATION; KINETIC CHARACTERISTICS; AROYLOXYL RADICALS; RECENT PROGRESS; PHOTOREDOX; LIGHT; ALKYLATION;
D O I：
10.1002/ejoc.202300166
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The exceptional versatility of carboxylic acids has been extensively exploited in organic synthesis across several decades. There has been a recent upsurge of radical decarboxylative transformations. The process can be initiated under mild conditions, and the resultant radicals have orthogonal reactivities to closed-shell species, thus providing immense opportunities for streamlining novel reactions. The use of free carboxylic acids is the most desirable owing to its high atom and step economy. Aiming to demonstrate the attractiveness of the strategy and to inspire chemists to tackle existing challenges, this review outlines the recent advances on radical decarboxylative functionalization of free carboxylic acids.
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收藏
页数：14
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