THE ROLE OF LIPID METABOLISM IN THE DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN DIABETIC NEPHROPATHY

The purpose of the study was to study the relationship between lipid metabolism and flow-mediated dilation and endothelium-independent vascular dilation in diabetic nephropathy patients. The study included 120 patients with chronic kidney disease against the background of diabetic nephropathy. They were divided into 4 groups according to the stages of disease. The level of flow-mediated dilation in the brachial artery was determined by the hyperemic test and the level of endothelium-independent vascular dilation by the nitroglycerin test. The lipid spectrum was assessed by the level of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins in blood serum, as well as by calculating the atherogenic coefficient. In the 1st group, a moderate inverse relationship was determined between flow-mediated dilation and total cholesterol, triglycerides, atherogenic coefficient (respectively, r=-0.503, p<0.05; r=-0.513, p<0 0.05; r=-0.531, p<0.05). At subsequent stages of chronic kidney disease, the correlation in the groups was of the same nature (0.726, p<0.01). Thus, the results obtained indicate the effect of changes in the blood lipid spectrum on the degree of flow-mediated dilation and absence of influence on endothelium-independent vascular dilation.