Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV

被引：3

作者：

Qing, Yulan ^{[1
]}

Chan, Ricky ^{[1
,2
]}

Fu, Pingfu ^{[1
,2
]}

Cullen, Jennifer ^{[1
,2
]}

Miron, Alexander ^{[1
,3
]}

Jacobson, Jeffrey M. ^{[4
]}

Pink, John ^{[1
]}

Gerson, Stanton L. ^{[1
,5
]}

机构：

[1] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH USA

[2] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA

[3] Case Western Reserve Univ, Dept Genet & Genom, Cleveland, OH USA

[4] Case Western Reserve Univ, Div Infect Dis & HIV Med, Cleveland, OH USA

[5] Case Western Reserve Univ, Sch Med, 10900 Euclid Ave, Cleveland, OH 44106 USA

来源：

CANCER MEDICINE | 2023年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

antiretroviral therapy; cancer; epigenetic aging; HIV; BIOLOGICAL AGE; INFECTION; ADULTS; ACCELERATION; INITIATION;

D O I：

10.1002/cam4.5809

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.Method: We evaluated whether premature aging in people living with HIV (PLWH) was associated with antiretroviral therapy (ART) or the diagnosis of cancer. We used well-established DNA methylation patterns to assess premature aging, using Horvath et al., in individuals with HIV located in Cleveland, Ohio and compared these to standardized datasets of US historical blood samples. Some of the PLWH developed cancer over time.Results: We found that DNA methylation analysis identified accelerated aging in PLWH whereas ART therapy mitigated the advancement of DNA methylation age. A variety of cancers were observed in this population, but a cancer diagnosis was not significantly associated with more advanced DNA methylation age.Conclusion: We find that the age acceleration detected in PLWH is mitigated by ART therapy and is not further accelerated by a diagnosis of cancer.

引用

页码：11010 / 11019

页数：10

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