A comment to improve tumor-treating fields therapy

被引:0
|
作者
Fioranelli, Massimo [1 ]
Sepehri, Alireza [1 ]
机构
[1] Ist Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, Italy
来源
AIMS BIOENGINEERING | 2023年 / 10卷 / 01期
关键词
tumor; TTFields; therapy; bubble; blood;
D O I
10.3934/bioeng.2023002
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Recent investigations have shown that special frequencies and intensities of electromagnetic waves could control the differentiations of some types of cells. Using this fact, tumor-treating fields (TTFields) therapy has been proposed as a technique which uses alternating electric fields of intermediate frequency (similar to 100-500 kHz) and low intensity (1-3 V/cm) to disrupt the cell divisions of tumors. However, this technique may have harmful effects on ionic liquids around normal cells. For example, electrodes could induce an extra electrical current within blood vessels. To observe these effects, we connected electrodes to a slide that includes water and some extra ions and put them under a 1000x microscope. We found that some ions, microbes and cells move toward negative electrons and some go away. These attractions of cells by electrodes could cause the destruction of the brain. We also found some electrical currents within the liquid emerge which absorb or repel water molecules and induce some bubbles. If these types of bubbles arise within the blood vessels, they can exert a force on the membranes of normal cells and destroy them. To avoid these problems, we suggest that electrodes should be replaced by some electromagnetic sender/receiver which emits some special frequencies. These frequencies could be absorbed only by blood vessels around the tumors because these vessels may be created only to provide the needed food for tumor cells and thus have a different potential and electrical current as compared to vessels around normal cells. Thus, these tumor vessels could act as the antenna for TTFields.
引用
收藏
页码:13 / 23
页数:11
相关论文
共 50 条
  • [41] Tumor Treating Fields: At the Crossroads Between Physics and Biology for Cancer Treatment
    Carrieri, Francesca A.
    Smack, Caleb
    Siddiqui, Ismaeel
    Kleinberg, Lawrence R.
    Tran, Phuoc T.
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [42] TUMOR TREATING FIELDS: MODELING AND A NUMERICAL ALGORITHM
    Shen, Jun
    Gong, Rongfang
    Chen, Chunxiao
    Wang, Liang
    Lin, Zhe
    Lo, Catharine w. k.
    Lu, Ming
    COMMUNICATIONS ON ANALYSIS AND COMPUTATION, 2024, 2 (02): : 159 - 179
  • [43] Targeting Accuracy Considerations for Simultaneous Tumor Treating Fields Antimitotic Therapy During Robotic Hypofractionated Radiation Therapy
    Biswas, Sharmi
    Kapitanova, Irina
    Divekar, Sabrina
    Grimm, Jimm
    Butterwick, Ian J.
    Garren, Daniel
    Kleinberg, Lawrence R.
    Redmond, Kristin J.
    Lacroix, Michel
    Mahadevan, Anand
    Forster, Kenneth M.
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2021, 20
  • [44] Transcriptomic Response to Tumor Treating Fields (TTFields) Across Tumor Types
    Katsir, K. Wainer
    Lavy-Shahaf, G.
    Fishman, H.
    Ene, H.
    Frechtel-Gerzi, R.
    Martinez-Conde, A.
    Dor-On, E.
    Davidi, S.
    Jacobovitch, S.
    Tzchori, I.
    Porat, Y.
    Ding, L.
    Story, M. D.
    Du, R.
    Kahlert, U.
    Mannarino, L.
    Mirimao, F.
    Lupi, M.
    D'Incalci, M.
    Haber, A.
    Giladi, M.
    Weinberg, U.
    Palti, Y.
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (11) : S431 - S431
  • [45] Tumor treating fields-effective, but at what cost?
    Zhang, Isabella
    Knisely, Jonathan P. S.
    TRANSLATIONAL CANCER RESEARCH, 2016, 5 : S1349 - S1353
  • [46] Body Fluids Modulate Propagation of Tumor Treating Fields
    Wong, Eric T.
    Lok, Edwin
    ADVANCES IN RADIATION ONCOLOGY, 2024, 9 (01)
  • [47] Tumor treating fields for glioblastoma: should it or will it ever be adopted?
    Thomas, Alissa A.
    Rauschkolb, Paula K.
    CURRENT OPINION IN NEUROLOGY, 2019, 32 (06) : 857 - 863
  • [48] Optimized Transcranial Brain Stimulation for Tumor Treating Fields
    Andrinolo O, Dante C.
    Fernandez-Corazza, Mariano
    Muravchik, Carlos H.
    ADVANCES IN BIOENGINEERING AND CLINICAL ENGINEERING, VOL 2, SABI 2023, 2024, 114 : 14 - 21
  • [49] Prevention and Management of Dermatologic Adverse Events Associated With Tumor Treating Fields in Patients With Glioblastoma
    Lacouture, Mario E.
    Anadkat, Milan J.
    Ballo, Matthew T.
    Iwamoto, Fabio
    Jeyapalan, Suriya A.
    La Rocca, Renato, V
    Schwartz, Margaret
    Serventi, Jennifer N.
    Glas, Martin
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [50] Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
    Porat, Yaara
    Giladi, Moshe
    Schneiderman, Rosa S.
    Blat, Roni
    Shteingauz, Anna
    Zeevi, Einav
    Munster, Mijal
    Voloshin, Tali
    Kaynan, Noa
    Tal, Orna
    Kirson, Eilon D.
    Weinberg, Uri
    Palti, Yoram
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (123):