A comment to improve tumor-treating fields therapy
被引:0
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作者:
Fioranelli, Massimo
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机构:
Ist Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, ItalyIst Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, Italy
Fioranelli, Massimo
[1
]
Sepehri, Alireza
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机构:
Ist Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, ItalyIst Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, Italy
Sepehri, Alireza
[1
]
机构:
[1] Ist Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, Italy
来源:
AIMS BIOENGINEERING
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2023年
/
10卷
/
01期
关键词:
tumor;
TTFields;
therapy;
bubble;
blood;
D O I:
10.3934/bioeng.2023002
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
Recent investigations have shown that special frequencies and intensities of electromagnetic waves could control the differentiations of some types of cells. Using this fact, tumor-treating fields (TTFields) therapy has been proposed as a technique which uses alternating electric fields of intermediate frequency (similar to 100-500 kHz) and low intensity (1-3 V/cm) to disrupt the cell divisions of tumors. However, this technique may have harmful effects on ionic liquids around normal cells. For example, electrodes could induce an extra electrical current within blood vessels. To observe these effects, we connected electrodes to a slide that includes water and some extra ions and put them under a 1000x microscope. We found that some ions, microbes and cells move toward negative electrons and some go away. These attractions of cells by electrodes could cause the destruction of the brain. We also found some electrical currents within the liquid emerge which absorb or repel water molecules and induce some bubbles. If these types of bubbles arise within the blood vessels, they can exert a force on the membranes of normal cells and destroy them. To avoid these problems, we suggest that electrodes should be replaced by some electromagnetic sender/receiver which emits some special frequencies. These frequencies could be absorbed only by blood vessels around the tumors because these vessels may be created only to provide the needed food for tumor cells and thus have a different potential and electrical current as compared to vessels around normal cells. Thus, these tumor vessels could act as the antenna for TTFields.
机构:
Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Peng, Junsong
Zhang, Liyang
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机构:
Cent South Univ, Xiangya Hosp, Natl Reg Ctr Neurol Dis, Dept Neurosurg, Nanchang, Jiangxi, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Zhang, Liyang
Wu, Yinghua
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Wu, Yinghua
Chen, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing 100853, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Chen, Ling
Liu, Zhixiong
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h-index: 0
机构:
Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Liu, Zhixiong
Liu, Fangkun
论文数: 0引用数: 0
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机构:
Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Liu, Fangkun
Zeng, Yu
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h-index: 0
机构:
Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USA
US Oncol Signature Healthcare Brockton, Dept Radiat Oncol, Brockton, MA 02302 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Lok, Edwin
San, Pyay
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
San, Pyay
White, Victoria
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
White, Victoria
Liang, Olivia
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Liang, Olivia
Widick, Page C.
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Widick, Page C.
Reddy, Sindhu Pisati
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USA
Southern Illinois Univ, Sch Med, Dept Neurol, Carbondale, IL USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Reddy, Sindhu Pisati
Wong, Eric T.
论文数: 0引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Neurooncol Unit, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Brain Tumor Ctr, Boston, MA 02215 USA
机构:
HonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Univ Arizona, Dept Med, Coll Med Phoenix, Phoenix, AZ USA
HonorHlth Res & Innovat Inst, 10510 N 92nd St Ste 200, Scottsdale, AZ 85258 USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Moser, Justin C.
Salvador, Ellaine
论文数: 0引用数: 0
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机构:
Univ Wurzburg, Dept Neurosurg, Sect Expt Neurosurg, Wurzburg, GermanyHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Salvador, Ellaine
Deniz, Karina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Med, Div Hematol Oncol & Transplant, Minneapolis, MN USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Deniz, Karina
Swanson, Kenneth
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Swanson, Kenneth
Tuszynski, Jack
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Phys, Edmonton, AB, CanadaHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Tuszynski, Jack
Carlson, Kristen W.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurosurg, Boston, MA USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Carlson, Kristen W.
Karanam, Narasimha Kumar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dept Radiat Oncol, Dallas, TX USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Karanam, Narasimha Kumar
Patel, Chirag B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX USA
Univ Texas MD Anderson Canc Ctr UTHlth, Neurosci & Canc Biol Grad Programs, Grad Sch Biomed Sci, Houston, TX USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Patel, Chirag B.
Story, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dept Radiat Oncol, Dallas, TX USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Story, Michael
Lou, Emil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Med, Div Hematol Oncol & Transplant, Minneapolis, MN USAHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
Lou, Emil
Hagemann, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wurzburg, Dept Neurosurg, Sect Expt Neurosurg, Wurzburg, GermanyHonorHlth Res & Innovat Inst, Scottsdale, AZ USA
机构:
Univ Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USAUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
Oberheim-Bush, Nancy Ann
Shi, Wenyin
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Radiat Oncol, Philadelphia, PA 19107 USAUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
Shi, Wenyin
McDermott, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Baptist Hlth South Florida, Miami Neurosci Inst, Div Neurosurg, Miami, FL USAUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
McDermott, Michael W.
Grote, Alexander
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Marburg, Dept Neurosurg, Marburg, GermanyUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
Grote, Alexander
Stindl, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Novocure GmbH, Med Safety, Munich, GermanyUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
Stindl, Julia
Lustgarten, Leonardo
论文数: 0引用数: 0
h-index: 0
机构:
Novocure Inc, Director Neurooncol Global Med Affairs, New York, NY USAUniv Calif San Francisco, UCSF Brain Tumor Ctr, Div Neurooncol, 400 Parnassus Ave,A808, San Francisco, CA 94143 USA
机构:
Novocure, Global Med Affairs, 1500 Broadway 17th Floor, New York, NY 10036 USANovocure, Global Med Affairs, 1500 Broadway 17th Floor, New York, NY 10036 USA