Advanced Nanomaterials for the Diagnosis and Treatment of Renal Cell Carcinoma

被引：6

作者：

Ji, Chen ^{[1
,2
,3
]}

Li, Junru ^{[1
,2
,3
]}

Mei, Junyang ^{[1
,2
,3
]}

Su, Weiran ^{[1
,2
,3
]}

Dai, Huili ^{[1
,2
,3
]}

Li, Fengqin ^{[1
,2
,3
]}

Liu, Peifeng ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, RenJi Hosp, Shanghai Canc Inst, Sch Med,State Key Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Cent Lab, Shanghai 200127, Peoples R China

[3] Shanghai Jiao Tong Univ, RenJi Hosp, Micronano Res & Diag Ctr, Sch Med, Shanghai 200127, Peoples R China

来源：

ADVANCED NANOBIOMED RESEARCH | 2023年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

diagnosis; drug delivery systems; nanomaterials; renal cell carcinoma; treatments; MESOPOROUS SILICA NANOPARTICLES; IN-VITRO; DRUG-DELIVERY; IMMOBILIZED-TRYPSIN; CANCER; THERAPY; TUMOR; CONTRAST; SIRNA; BIODISTRIBUTION;

D O I：

10.1002/anbr.202200079

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Renal cell carcinoma (RCC) is the most common type of kidney cancer. Owing to the high morbidity rate of RCC, there is an urgent need for intensive research on robust materials to diagnose and treat RCC. Nanomaterials have been developed largely in the last three decades because of their numerous advantages, such as high specific surface area, simple surface functionalization, rapid onset of therapeutic action, superior biological activity, and other unique physical-chemical characteristics. Herein, first, various types of nanomaterials used in RCC treatment are introduced, including inorganic nanomaterials, lipid nanomaterials, synthetic polymer nanomaterials, and natural nanomaterials. Second, the different diagnosis and therapeutic mechanisms of nanomaterials in the kidneys are reviewed and these advantages of nanomaterials are highlighted. Furthermore, nanomaterials are investigated for the preclinical and clinical detection and treatment of RCC. Finally, the challenges and outlook of various nanomaterials for RCC diagnostic and treatment are discussed.

引用

页数：14

共 110 条

[1] A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma [J].