High-resolution multi-reflection time-of-flight mass spectrometer with atmospheric pressure interface

被引：0
|
作者：
Yan, Shuxiong [1 ,2 ]
Ren, Yi [1 ,3 ,5 ]
Huang, Qi [1 ,4 ]
Hong, Yi [3 ]
Chen, Zhengge [1 ,4 ]
Li, Mei [1 ]
Hu, Bin [1 ,5 ]
Huang, Zhengxu [1 ,3 ,5 ]
机构：
[1] Jinan Univ, Inst Mass Spectrometry & Atmospher Environm, Guangzhou, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
[3] Guangzhou Hexin Instrument Co Ltd, Guangzhou, Peoples R China
[4] Guangdong MS Inst Sci Instrument Innovat, Guangzhou, Peoples R China
[5] Jinan Univ, Inst Mass Spectrometry & Atmospher Environm, Guangzhou 510632, Peoples R China
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2024年 / 38卷 / 11期
基金：
中国国家自然科学基金;
关键词：
ONLY QUADRUPOLE; SPECTROGRAPH; RF;
D O I：
10.1002/rcm.9742
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
RationaleAtmospheric pressure interface multi-reflection time-of-flight mass spectrometry (API-MRTOF-MS) has the potential to be a rapid and high-resolution analytical tool for versatile applications in chemistry, biology, environmental science, and medicine.MethodsThe ions were reflected in a mass analyzer via electrostatic mirrors and folded flight path. Therefore, flight distances were significantly increased. The ion flight path of the API-MRTOF-MS was extended from meters to over 1 km, and the mass resolution was increased. Furthermore, the mass analysis could be completed at around 10 ms due to the rapid response of TOF-MS.ResultsA high-resolution API-MRTOF-MS approach is successfully developed in this study. The mass resolution could achieve 116 050 (full widths at half maximum [FWHM]) for Cs+ ions using an atmospheric pressure electrospray ionization within a total TOF of only 18 ms. An ion transmission efficiency of over 50% was achieved after 600 cycles.ConclusionsThe analytical performance of the newly developed API-MRTOF-MS demonstrated that it is suitable for high resolution and rapid analysis in many fields.
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页数：8
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