High-resolution multi-reflection time-of-flight mass spectrometer with atmospheric pressure interface

被引：0
|
作者：
Yan, Shuxiong [1 ,2 ]
Ren, Yi [1 ,3 ,5 ]
Huang, Qi [1 ,4 ]
Hong, Yi [3 ]
Chen, Zhengge [1 ,4 ]
Li, Mei [1 ]
Hu, Bin [1 ,5 ]
Huang, Zhengxu [1 ,3 ,5 ]
机构：
[1] Jinan Univ, Inst Mass Spectrometry & Atmospher Environm, Guangzhou, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
[3] Guangzhou Hexin Instrument Co Ltd, Guangzhou, Peoples R China
[4] Guangdong MS Inst Sci Instrument Innovat, Guangzhou, Peoples R China
[5] Jinan Univ, Inst Mass Spectrometry & Atmospher Environm, Guangzhou 510632, Peoples R China
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2024年 / 38卷 / 11期
基金：
中国国家自然科学基金;
关键词：
ONLY QUADRUPOLE; SPECTROGRAPH; RF;
D O I：
10.1002/rcm.9742
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
RationaleAtmospheric pressure interface multi-reflection time-of-flight mass spectrometry (API-MRTOF-MS) has the potential to be a rapid and high-resolution analytical tool for versatile applications in chemistry, biology, environmental science, and medicine.MethodsThe ions were reflected in a mass analyzer via electrostatic mirrors and folded flight path. Therefore, flight distances were significantly increased. The ion flight path of the API-MRTOF-MS was extended from meters to over 1 km, and the mass resolution was increased. Furthermore, the mass analysis could be completed at around 10 ms due to the rapid response of TOF-MS.ResultsA high-resolution API-MRTOF-MS approach is successfully developed in this study. The mass resolution could achieve 116 050 (full widths at half maximum [FWHM]) for Cs+ ions using an atmospheric pressure electrospray ionization within a total TOF of only 18 ms. An ion transmission efficiency of over 50% was achieved after 600 cycles.ConclusionsThe analytical performance of the newly developed API-MRTOF-MS demonstrated that it is suitable for high resolution and rapid analysis in many fields.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] A high-resolution multi-reflection time-of-flight mass spectrograph for precision mass measurements at RIKEN/SLOWRI
    Schury, P.
    Wada, M.
    Ito, Y.
    Arai, F.
    Naimi, S.
    Sonoda, T.
    Wollnik, H.
    Shchepunov, V. A.
    Smorra, C.
    Yuan, C.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2014, 335 : 39 - 53
  • [2] Design of the multi-reflection time-of-flight mass spectrometer for the RAON facility
    Yoon, J. W.
    Park, Y. -H.
    Park, S. J.
    Kim, G. D.
    Kim, Y. K.
    INPC 2013 - INTERNATIONAL NUCLEAR PHYSICS CONFERENCE, VOL. 2, 2014, 66
  • [3] ISOLTRAP's multi-reflection time-of-flight mass separator/spectrometer
    Wolf, R. N.
    Wienholtz, F.
    Atanasov, D.
    Beck, D.
    Blaum, K.
    Borgmann, Ch
    Herfurth, F.
    Kowalska, M.
    Kreim, S.
    Litvinov, Yu A.
    Lunney, D.
    Manea, V.
    Neidherr, D.
    Rosenbusch, M.
    Schweikhard, L.
    Stanja, J.
    Zuber, K.
    INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2013, 349 : 123 - 133
  • [4] The performance of the commissioned Notre Dame multi-reflection time-of-flight mass spectrometer
    Liu, B.
    Brodeur, M.
    Burdette, D. P.
    Kelly, J. M.
    Kim, T.
    Long, J.
    O'Malley, P. D.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2021, 985
  • [5] A multi-reflection time-of-flight mass spectrometer for the offline ion source of the PUMA experiment
    Schlaich, M.
    Fischer, J.
    Fischer, P.
    Klink, C.
    Obertelli, A.
    Schmidt, A.
    Schweikhard, L.
    Wienholtz, F.
    INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2024, 495
  • [6] Construction and simulation of a multi-reflection time-of-flight mass spectrometer at the University of Notre Dame
    Schultz, B. E.
    Kelly, J. M.
    Nicoloff, C.
    Long, J.
    Ryan, S.
    Brodeur, M.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2016, 376 : 251 - 255
  • [7] Development of A High-performance Rectangular Ion Trap for Multi-reflection Time-of-Flight Mass Spectrometer
    Chen, Xiao-Xia
    Ren, Yi
    Huang, Qi
    Xiang, Da-Jun
    Li, Chang-Wei
    Hong, Yi
    Li, Lei
    Huang, Zheng-Xu
    Li, Mei
    Xu, Jing-Wei
    Zhou, Zhen
    CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2025, 53 (01) : 38 - 46
  • [8] HIGH-RESOLUTION TIME-OF-FLIGHT MASS-SPECTROMETER
    BERGMANN, T
    MARTIN, TP
    SCHABER, H
    REVIEW OF SCIENTIFIC INSTRUMENTS, 1989, 60 (04): : 792 - 793
  • [9] A multi-reflection time-of-flight mass spectrometer for mass measurements of short-lived nuclei
    Ishida, Y
    Wada, M
    Wollnik, H
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2005, 241 (1-4): : 983 - 985
  • [10] Towards ultrahigh-resolution multi-reflection time-of-flight mass spectrometry at ISOLTRAP
    Wienholtz, F.
    Atanasov, D.
    Kreim, S.
    Manea, V.
    Rosenbusch, M.
    Schweikhard, L.
    Welker, A.
    Wolf, R. N.
    PHYSICA SCRIPTA, 2015, T166
12345