How clonal hematopoiesis promotes inflammation at a single-cell level

被引：1
作者：
Chavkin, Nicholas W. [1 ]
Evans, Megan A. [1 ]
Walsh, Kenneth [1 ]
机构：
[1] Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA
来源：
NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 09期
关键词：
HEART-FAILURE; DNMT3A; TET2;
D O I：
10.1038/s44161-023-00323-w
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A method to identify and analyze clonal hematopoiesis in clinical blood samples at single-cell resolution reveals cell-intrinsic and paracrine effects of DNMT3A mutations in circulating monocytes, T cells and natural killer cells in the setting of heart failure.
引用
收藏
页码：801 / 802
页数：2
相关论文
共 12 条
  • [1] Cell-intrinsic effects of clonal hematopoiesis in heart failure
    Abplanalp, Wesley T.
    Schuhmacher, Bianca
    Cremer, Sebastian
    Merten, Maximilian
    Shumliakivska, Mariana
    Macinkovic, Igor
    Zeiher, Andreas M.
    John, David
    Dimmeler, Stefanie
    [J]. NATURE CARDIOVASCULAR RESEARCH, 2023, 2 (09): : 819 - +
  • [2] Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations
    Assmus, Birgit
    Cremer, Sebastian
    Kirschbaum, Klara
    Culmann, David
    Kiefer, Katharina
    Dorsheimer, Lena
    Rasper, Tina
    Abou-El-Ardat, Khalil
    Herrmann, Eva
    Berkowitsch, Alexander
    Hoffmann, Jedrzej
    Seeger, Florian
    Mas-Peiro, Silvia
    Rieger, Michael A.
    Dimmeler, Stefanie
    Zeiher, Andreas M.
    [J]. EUROPEAN HEART JOURNAL, 2021, 42 (03) : 257 - 265
  • [3] Importance of clonal hematopoiesis in heart failure
    Chavkin, Nicholas W.
    Min, Kyung-Duk
    Walsh, Kenneth
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2022, 32 (04) : 198 - 203
  • [4] Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure
    Cremer, Sebastian
    Kirschbaum, Klara
    Berkowitsch, Alexander
    John, David
    Kiefer, Katharina
    Dorsheimer, Lena
    Wagner, Julian
    Rasper, Tina
    Abou-El-Ardat, Khalil
    Assmus, Birgit
    Serve, Hubert
    Rieger, Michael
    Dimmeler, Stefanie
    Zeiher, Andreas M.
    [J]. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020, 13 (04): : E003003
  • [5] CLONAL HEMATOPOIESIS, SOMATIC MOSAICISM, AND AGE-ASSOCIATED DISEASE
    Evans, Megan A.
    Walsh, Kenneth
    [J]. PHYSIOLOGICAL REVIEWS, 2023, 103 (01) : 649 - 716
  • [6] Clonal haematopoiesis and cardiovascular disease: how low can you go?
    Evans, Megan A.
    Sano, Soichi
    Walsh, Kenneth
    [J]. EUROPEAN HEART JOURNAL, 2021, 42 (03) : 266 - 268
  • [7] Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
    Fuster, Jose J.
    MacLauchlan, Susan
    Zuriaga, Maria A.
    Polackal, Maya N.
    Ostriker, Allison C.
    Chakraborty, Raja
    Wu, Chia-Ling
    Sano, Soichi
    Muralidharan, Sujatha
    Rius, Cristina
    Vuong, Jacqueline
    Jacob, Sophia
    Muralidhar, Varsha
    Robertson, Avril A. B.
    Cooper, Matthew A.
    Andres, Vicente
    Hirschi, Karen K.
    Martin, Kathleen A.
    Walsh, Kenneth
    [J]. SCIENCE, 2017, 355 (6327) : 842 - 847
  • [8] Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction
    Pascual-Figal, Domingo A.
    Bayes-Genis, Antoni
    Diez-Diez, Miriam
    Hernandez-Vicente, Alvaro
    Vazquez-Andres, David
    de la Barrera, Jorge
    Vazquez, Enrique
    Quintas, Ana
    Zuriaga, Maria A.
    Asensio-Lopez, Mari C.
    Dopazo, Ana
    Sanchez-Cabo, Fatima
    Fuster, Jose J.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (14) : 1747 - 1759
  • [9] CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease
    Sano, Soichi
    Oshima, Kosei
    Wang, Ying
    Katanasaka, Yasufumi
    Sano, Miho
    Walsh, Kenneth
    [J]. CIRCULATION RESEARCH, 2018, 123 (03) : 335 - 341
  • [10] Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
    Steensma, David P.
    Bejar, Rafael
    Jaiswal, Siddhartha
    Lindsley, R. Coleman
    Sekeres, Mikkael A.
    Hasserjian, Robert P.
    Ebert, Benjamin L.
    [J]. BLOOD, 2015, 126 (01) : 9 - 16
12