Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

被引：3

作者：

Valizadeh, Mehrdad ^{[1
]}

Derafsh, Ehsan ^{[2
]}

Abyaneh, Fahimeh Abdi ^{[3
]}

Parsamatin, Sayedeh Kiana ^{[4
]}

Noshabad, Fatemeh Zahra Rashidi ^{[5
]}

Alinaghipour, Azam ^{[6
]}

Yaghoobi, Zahra ^{[7
,8
]}

Taheri, Abdolkarim Talebi ^{[9
]}

Dadgostar, Ehsan ^{[10
,11
]}

Aschner, Michael ^{[12
]}

Mirzaei, Hamed ^{[13
]}

Tamtaji, Omid Reza ^{[7
,8
]}

Nabavizadeh, Fatemeh ^{[7
,8
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Tehran, Iran

[2] Windsor Univ, Sch Med, Cayon, ON, Canada

[3] Kashan Univ Med Sci, Sch Med, Kashan, Iran

[4] Isfahan Univ Med Sci, Sch Med, Dept Neurol, Esfahan, Iran

[5] Kashan Univ Med Sci, Student Res Comm, Kashan, IR, Iran

[6] Islamic Azad Univ, Sch Med Sci, Yazd Branch, Yazd, Iran

[7] Univ Tehran Med Sci, Neurosci Inst, Electrophysiol Res Ctr, Tehran, IR, Iran

[8] Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran, IR, Iran

[9] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[10] Isfahan Univ Med Sci, Behav Sci Res Ctr, Esfahan, IR, Iran

[11] Isfahan Univ Med Sci, Student Res Comm, Esfahan, IR, Iran

[12] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[13] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, IR, Iran

来源：

MOLECULAR NEUROBIOLOGY | 2023年 / 61卷 / 7期

关键词：

Neurodegenerative disorders; Apoptosis; MicroRNA; Long non-coding RNA; Circular RNA; INDUCED NEURONAL INJURY; 6-HYDROXYDOPAMINE-INDUCED CELL MODEL; ALPHA-SYNUCLEIN AGGREGATION; INDUCED PARKINSONS-DISEASE; BETA-INDUCED NEUROTOXICITY; AMYLOID PRECURSOR PROTEIN; OXIDATIVE STRESS INJURY; ALZHEIMERS-DISEASE; TAU-PHOSPHORYLATION; DOPAMINERGIC-NEURONS;

D O I：

10.1007/s12035-023-03849-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis.

引用

页码：4508 / 4537

页数：30

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