The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis

被引：3
作者：
Kamon, Toshitaka [1 ]
Horie, Shotaro [1 ]
Inaba, Tomoya [1 ]
Ito, Nobuo [1 ]
Shiraki, Katsuya [2 ]
Ichikawa, Yuhuko [3 ]
Ezaki, Minoru [3 ]
Shimpo, Hideto [4 ]
Shimaoka, Motomu [5 ]
Nishigaki, Akisato [6 ]
Shindo, Akihiro [6 ]
Wada, Hideo [2 ]
机构：
[1] Mie Prefectural Gen Med Ctr, Dept Neurol, Yokaichi, Japan
[2] Mie Prefectural Gen Med Ctr, Dept Gen & Lab Med, Yokaichi 5108561, Japan
[3] Mie Prefectural Gen Med Ctr, Dept Cent Lab, Yokaichi, Japan
[4] Mie Prefectural Gen Med Ctr, Yokaichi, Japan
[5] Mie Univ, Dept Mol Pathobiol & Cell Adhes Biol, Grad Sch Med, Tsu, Japan
[6] Mie Univ, Dept Neurol, Grad Sch Med, Tsu, Japan
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2023年 / 29卷
关键词：
CWA; APTT; sTF; FIXa; acute cerebral infarction; hypercoagulable state; PLATELET;
D O I：
10.1177/10760296231161591
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A few studies concerning hypercoagulable states have sufficiently been reported in patients with acute cerebral infarction (ACI), as ACI is generally considered to be caused by platelet activation. Clot waveform analyses (CWA) for activated partial thromboplastin time (APTT) and small amount of tissue factor FIX activation assay (sTF/FIXa) were examined in 108 patients with ACI, 61 patients without ACI, and 20 healthy volunteers. CWA-APTT and CWA-sTF/FIXa showed that the peak heights were significantly higher in ACI patients without anticoagulant therapy than in healthy volunteers. Absorbance exceeding 78.1 mm on the 1(st) DPH in the CWA-sTF/FIXa showed the highest odds ratio for ACI. The peak heights were significantly lower in the CWA-sTF/FIXa of ACI patients receiving argatroban therapy than in those of ACI patients without anticoagulant therapy. CWA can suggest a hypercoagulable state in ACI patients and may be useful for monitoring the need for anticoagulant therapy.
引用
收藏
页数：9
相关论文
共 27 条
  • [1] Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
    Amarenco, Pierre
    Denison, Hans
    Evans, Scott R.
    Himmelmann, Anders
    James, Stefan
    Knutsson, Mikael
    Ladenvall, Per
    Molina, Carlos A.
    Wang, Yongjun
    Johnston, S. Claiborne
    [J]. JAMA NEUROLOGY, 2021, 78 (02) : 177 - 185
  • [2] Impact of Circadian Blood Pressure Pattern on Silent Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis
    Chokesuwattanaskul, Anthipa
    Cheungpasitporn, Wisit
    Thongprayoon, Charat
    Vallabhajosyula, Saraschandra
    Bathini, Tarun
    Mao, Michael A.
    Cato, Liam D.
    Chokesuwattanaskul, Ronpichai
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (12):
  • [3] Prediction of the haemostatic effects of bypassing therapy using comprehensive coagulation assays in emicizumab prophylaxis-treated haemophilia A patients with inhibitors
    Furukawa, Shoko
    Nogami, Keiji
    Shimonishi, Naruto
    Nakajima, Yuto
    Matsumoto, Taisei
    Shima, Midori
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2020, 190 (05) : 727 - 735
  • [4] Gerotziafas GT, 2020, THROMB RES, V191, pS50, DOI 10.1016/S0049-3848(20)30397-2
  • [5] The Evaluation of Hemostatic Abnormalities Using a CWA-Small Amount Tissue Factor Induced FIX Activation Assay in Major Orthopedic Surgery Patients
    Hasegawa, Masahiro
    Tone, Shine
    Wada, Hideo
    Naito, Yohei
    Matsumoto, Takeshi
    Yamashita, Yoshiki
    Shimaoka, Motomu
    Sudo, Akihiro
    [J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2021, 27
  • [6] Cancer-associated pathways and biomarkers of venous thrombosis
    Hisada, Yohei
    Mackman, Nigel
    [J]. BLOOD, 2017, 130 (13) : 1499 - 1506
  • [7] RETRACTED: Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings (Retracted article. See vol. 85, pg. 170, 2022)
    Huang, Pan
    He, Xiao-ying
    Xu, Min
    [J]. EUROPEAN NEUROLOGY, 2021, 84 (01) : 38 - 42
  • [8] A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms
    Kobayashi, Mayu
    Wada, Hideo
    Fukui, Shunsuke
    Mizutani, Hiroki
    Ichikawa, Yuhuko
    Shiraki, Katsuya
    Moritani, Isao
    Inoue, Hidekazu
    Shimaoka, Motomu
    Shimpo, Hideto
    [J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (22)
  • [9] Clinical Application of Thromboelastography/Thromboelastometry (TEG/TEM) in the Neonatal Population: A Narrative Review
    Konstantinidi, Aikaterini
    Sokou, Rozeta
    Parastatidou, Stavroula
    Lampropoulou, Katerina
    Katsaras, George
    Boutsikou, Theodora
    Gounaris, Antonios K.
    Tsantes, Argyrios E.
    Iacovidou, Nicoletta
    [J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2019, 45 (05) : 449 - 457
  • [10] Cerebral Ischemia in Patients on Direct Oral Anticoagulants Plasma Levels Are Associated With Stroke Severity
    Macha, Kosmas
    Marsch, Armin
    Siedler, Gabriela
    Breuer, Lorenz
    Strasser, Erwin F.
    Engelhorn, Tobias
    Schwab, Stefan
    Kallmuenzer, Bernd
    [J]. STROKE, 2019, 50 (04) : 873 - 879
123