Addition of Alcohols onto Electron-Deficient Heteroarenium Salts: A Reversible Covalent Bonding Process under Basic Conditions

被引：0

作者：

Chen, Baoli ^{[1
]}

Li, En ^{[3
]}

Song, Feifei ^{[1
]}

Guimond, Nicolas ^{[4
]}

Chen, Jiean ^{[1
,3
]}

Huang, Yong ^{[2
]}

机构：

[1] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Clear Water Bay, Hong Kong, Peoples R China

[3] Pingshan Translat Med Ctr, Shenzhen Bay Lab, Shenzhen 518055, Peoples R China

[4] Bayer AG Crop Sci, Proc Res, D-40789 Monheim, Germany

来源：

SYNLETT | 2023年 / 34卷 / 09期

基金：

中国国家自然科学基金;

关键词：

heteroarenium salts; alcohols; reversible addition; basic conditions; HYDROGEN-PEROXIDE; CATALYSIS; PYRIDINIUM; INTERMEDIATE; OXIDATIONS; ACTIVATION; STRATEGIES;

D O I：

10.1055/a-2005-5372

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reversible addition of benzyl alcohol onto heteroarenium salts under basic conditions was studied. Fine-tuning of the nature of the arenium and substituents allowed the discovery of a range of pyrimidinium substrates that can undergo C6-selective alcohol addition. Crossover experiments were also performed to confirm the addition elimination equilibrium under basic conditions.

引用

页码：1042 / 1048

页数：7