Lactate and glucose induced self-assembly of hydrophobic boronic acid-substituted polymers

被引：3

作者：

Dhiraj, Harpal S. ^{[1
]}

Ishizuka, Fumi ^{[2
]}

Elshaer, Amr ^{[1
]}

Zetterlund, Per B. ^{[2
]}

Aldabbagh, Fawaz ^{[1
]}

机构：

[1] Kingston Univ, Sch Life Sci Pharm & Chem, Dept Pharm, Penrhyn Rd, Kingston Upon Thames KT1 2EE, England

[2] Univ New South Wales, Sch Chem Engn, Cluster Adv Macromol Design CAMD, Sydney, NSW 2052, Australia

来源：

JOURNAL OF POLYMER SCIENCE | 2023年 / 61卷 / 08期

关键词：

block copolymers; core-shell nanoparticle; RAFT; RDRP; COPOLYMER; POLYMERIZATION; NANOPARTICLES; MICELLES;

D O I：

10.1002/pol.20220766

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Amphiphilic boronic acid (BA)-substituted block copolymers have been utilized in biomedical applications through binding to saccharides, including to glucose whereas binding to the anaerobically produced metabolite lactate is unreported. Glucose requires basic conditions, while lactate binding occurs at neutral physiological conditions. Herein, BA binding to glucose and lactate is used for the first time to convert solvated hydrophobic homopolymer and hydrophobic block copolymers to amphiphilic core-shell nanoparticle spheres and worms.

引用

页码：723 / 733

页数：11

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