Changes in physical activity and the risk of heart failure in newly diagnosed patients with depression: A nationwide cohort study

Background: Depression is known to increase the risk of heart failure (HF), and physical activity could be a potential mediator of their linkage. In this study, we examined the risk of incident HF according to changes in the level of physical activity before and after the diagnosis of depression.Methods: A South Korean National Health Insurance Sharing Service database was used. A total of 1,405,655 patients with newly diagnosed depression were included in the analyses. According to the changes in physical activity based on the recommended level of regular physical activity, participants were divided into four groups: never, beginning, maintenance, and discontinuation. The main outcome was the occurrence of HF.Results: During the average follow-up period of 5.28 years (SD, 2.00 years), 69,338 participants were diagnosed with HF, with an incidence rate of 9.34 per 1000 person-years. Compared to the never group, the beginning group showed a decreased risk of HF (aHR, 0.88; 95% CI, 0.86-0.90). Compared to the maintenance group, the discontinuation group showed an increased risk of HF (aHR, 1.16; 95% CI, 1.11-1.20).Conclusions: In the patients with depression, beginning regular physical activity was associated with a decreased risk of HF, and discontinuing regular physical activity was associated with an increased risk.