Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2-hydroxy-1-naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

被引：25
作者：
Dalal, Mahak [1 ]
Devi, Jai [2 ]
Antil, Nidhi [1 ]
Kumar, Binesh [2 ]
Verma, Yogesh Kumar [3 ]
Kumar, Subodh [3 ]
Wati, Mukhan [1 ]
Garg, Sapana [1 ]
机构：
[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India
[2] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India
[3] Def Res & Dev Org DRDO, Inst Nucl Med & Allied Sci INMAS, Stem Cell & Tissue Engn Res Grp, New Delhi 110054, India
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2024年 / 38卷 / 02期
关键词：
ADMET; cytotoxicity; DFT; Organyltellurium; Schiff base; IN-VITRO; MOLECULAR DOCKING; ANTIBACTERIAL; ELUCIDATION; DISCOVERY; STATE;
D O I：
10.1002/aoc.7338
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study, Schiff base ligand 1,1 '-((propane-1,3-diylbis [azaneylylidene]) bis (methaneylylidene))bis (naphthalen-2-ol) based Organyltellurium (IV) complexes were synthesized with formulae C32H27ClN2O3Te (5a)\C31H25ClN2O3Te (5b)\C32H27ClN2O3Te (5c)\ C39H34N2O4Te (5d)\ C37H30N2O4Te (5e)\ C39H34N2O4Te (5f) for acquiring a potential therapeutic agent. The synthesized compounds were characterized by ultraviolet-visible (UV-Vis), FT-IR, 1H-NMR, 13C-NMR, mass spectrometry, molar conductance, elemental analysis, powder X-ray diffraction and EDAX, which states that the tetradentate Schiff base ligand (HNDP) coordinated via oxygen and nitrogen atom with tellurium giving hexa-coordinated tellurium (IV) complexes. The thermal features of the ligand and complexes were studied using thermal (TGA and DTG) technique. The biochemical behavior of the Schiff base and its complexes was assessed by examining their reactivity against various microbial strains, DPPH free radicals as well as normal and cancer cells. The complex 5c exhibited the highest inhibition activity against bacterial strains while complex 5f showed the strongest inhibition activity against fungal strains. Complexes 5e and 5f displayed the most effective suppression of DPPH free radicals. The results of in vitro cytotoxicity study revealed that complex 5a demonstrated moderate cytotoxic effect on the L929 cell lines. Complex 5c displayed a significant cytotoxic effect on the PC3 cell line. Moreover, complex 5a, 5c and 5e exhibited the best cytotoxic activity against the Saos-2 cell line. Additionally, the structural forms of synthesized compounds were elucidated by DFT study. Furthermore, pharmacokinetic ADMET properties were estimated for their drug similarity behavior. The results advocate that complexes can be utilized as biological drugs. Biological Nature, Structure Elucidation and Theoretical Analysis of Organyltellurium (IV) Complexes.image
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页数：17
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共 89 条
[1]   Carbonic anhydrase inhibition of Schiff base derivative of imino-methyl-naphthalen-2-ol: Synthesis, structure elucidation, molecular docking, dynamic simulation and density functional theory calculations [J].
Abbas, Saghir ;
Nasir, Hafiza Huma ;
Zaib, Sumera ;
Ali, Saqib ;
Mahmood, Tariq ;
Ayub, Khurshid ;
Tahir, Muhammad Nawaz ;
Iqbal, Jamshed .
JOURNAL OF MOLECULAR STRUCTURE, 2018, 1156 :193-200
[2]   Pyrazole Schiff Base Hybrids as Anti-Malarial Agents: Synthesis, In Vitro Screening and Computational Study [J].
Aggarwal, Shilpy ;
Paliwal, Deepika ;
Kaushik, Dhirender ;
Gupta, Girish Kumar ;
Kumar, Ajay .
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2018, 21 (03) :194-203
[3]   Green synthesis approach for novel benzenesulfonamide nanometer complexes with elaborated spectral, theoretical and biological treatments [J].
Al-Fahemi, Jabir H. ;
Khedr, Abdalla M. ;
Althagafi, Ismail ;
El-Metwaly, Nashwa M. ;
Saad, Fawaz A. ;
Katouah, Hanadi A. .
APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (09)
[4]   Synthesis and In Vitro Anti-HIV Activity of Some New Schiff Base Ligands Derived from 5-Amino-4-phenyl-4H-1,2,4-triazole-3-thiol and Their Metal Complexes [J].
Al-Masoudi, Najim A. ;
Aziz, Nazik M. ;
Mohammed, Abdulalah T. .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (11) :2891-2901
[5]   The discovery and development of cisplatin [J].
Alderden, RA ;
Hall, MD ;
Hambley, TW .
JOURNAL OF CHEMICAL EDUCATION, 2006, 83 (05) :728-734
[6]   Syntheses, crystal structures, antioxidant, in silico DNA and SARS-CoV-2 interaction studies of triorganotin(IV) carboxylates [J].
Ali, Tariq ;
Muhammad, Niaz ;
Ali, Zafar ;
Samad, Abdus ;
Ibrahim, Mohammad ;
Ikram, Muhammad ;
Rehman, Sadia ;
Shujah, Shaukat ;
Khan, Gul Shahzada ;
Wadood, Abdul ;
Ali, Saqib ;
Schulzke, Carola .
JOURNAL OF MOLECULAR STRUCTURE, 2021, 1234
[7]   Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand [J].
Alorini, Thamer A. ;
Al-Hakimi, Ahmed N. ;
Saeed, S. El-Sayed ;
Alhamzi, Ebtesam Hassan Lutf ;
Albadri, Abuzar E. A. E. .
ARABIAN JOURNAL OF CHEMISTRY, 2022, 15 (02)
[8]   Synthesis and characterization for new Zn(II) complexes and their optimizing fertilization performance in planting corn hybrid [J].
Althagafi, Ismail ;
Morad, Moataz ;
Al-dawood, Aisha Y. ;
Ibraheem, Farag ;
Yarkandy, Naema ;
Katouah, Hanadi A. ;
Hossan, Aisha S. ;
Khedr, Abdalla M. ;
El-Metwaly, Nashwa M. .
CHEMICAL PAPERS, 2021, 75 (05) :2121-2133
[9]   Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations [J].
Althagafi, Ismail ;
El-Metwaly, Nashwa M. ;
Elghalban, Marwa G. ;
Farghaly, Thoraya A. ;
Khedr, Abdalla M. .
BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2018, 2018
[10]   Synthesis, and characterization of cobalt(III) complexes with Schiff bases derived from 2-hydroxynaphthaldehyde, (naph)2dien and (naph)2dpt, and monodentate amine ligands: Crystal structure, spectral and redox properties [J].
Amirnasr, Mehdi ;
Fadaee, Farzaneh ;
Mereiter, Kurt .
INORGANICA CHIMICA ACTA, 2011, 371 (01) :6-12
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