Orai1 Ca2+channel modulators as therapeutic tools for treating cancer: Emerging evidence!

被引：7
作者：
Mignen, Olivier [1 ]
Vannier, Jean -Pierre [2 ]
Schneider, Pascale [2 ]
Renaudineau, Yves [3 ]
Abdoul-Azize, Souleymane [1 ,2 ,4 ]
机构：
[1] Univ Brest, LBAI, UMR1227, Brest, France
[2] Normandie Univ, UNIROUEN, INSERM, U1234, F-76000 Rouen, France
[3] Univ Toulouse III, Lab Immunol, CHU Purpan Toulouse, INSERM U1291,CNRS U5051, F-31062 Toulouse, France
[4] Rouen Normandie Univ, Fac Med & Pharm, UMR INSERM U1234, F-76000 Rouen, France
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 219卷
基金：
美国国家卫生研究院;
关键词：
Calcium; SOCE; Orai1; Cancer; Orai1 channel modulators; Therapeutics; OPERATED CA2+ ENTRY; CAPACITATIVE CALCIUM-ENTRY; RENAL-CELL CARCINOMA; CRAC CHANNELS; PROSTATE-CANCER; ELEVATED ORAI1; POOR-PROGNOSIS; PHASE-II; STIM1; EXPRESSION;
D O I：
10.1016/j.bcp.2023.115955
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways. Deregulation of these pathways contribute to increased tumor cell proliferation, migration, metastasis, and angiogenesis. Among Orais, Orai1 is an attractive therapeutic target explaining the development of specific modulators. Therapeutic trials using Orai1 channel inhibitors have been evaluated for treating diverse diseases such as psoriasis and acute pancreatitis, and emerging data suggest that Orai1 channel modulators may be beneficial for cancer treatment. This review discusses herein the importance of Orai1 channel modulators as potential therapeutic tools and the added value of these modulators for treating cancer.
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页数：11
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