Orai1 Ca2+channel modulators as therapeutic tools for treating cancer: Emerging evidence!

被引：6
作者：
Mignen, Olivier [1 ]
Vannier, Jean -Pierre [2 ]
Schneider, Pascale [2 ]
Renaudineau, Yves [3 ]
Abdoul-Azize, Souleymane [1 ,2 ,4 ]
机构：
[1] Univ Brest, LBAI, UMR1227, Brest, France
[2] Normandie Univ, UNIROUEN, INSERM, U1234, F-76000 Rouen, France
[3] Univ Toulouse III, Lab Immunol, CHU Purpan Toulouse, INSERM U1291,CNRS U5051, F-31062 Toulouse, France
[4] Rouen Normandie Univ, Fac Med & Pharm, UMR INSERM U1234, F-76000 Rouen, France
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 219卷
基金：
美国国家卫生研究院;
关键词：
Calcium; SOCE; Orai1; Cancer; Orai1 channel modulators; Therapeutics; OPERATED CA2+ ENTRY; CAPACITATIVE CALCIUM-ENTRY; RENAL-CELL CARCINOMA; CRAC CHANNELS; PROSTATE-CANCER; ELEVATED ORAI1; POOR-PROGNOSIS; PHASE-II; STIM1; EXPRESSION;
D O I：
10.1016/j.bcp.2023.115955
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways. Deregulation of these pathways contribute to increased tumor cell proliferation, migration, metastasis, and angiogenesis. Among Orais, Orai1 is an attractive therapeutic target explaining the development of specific modulators. Therapeutic trials using Orai1 channel inhibitors have been evaluated for treating diverse diseases such as psoriasis and acute pancreatitis, and emerging data suggest that Orai1 channel modulators may be beneficial for cancer treatment. This review discusses herein the importance of Orai1 channel modulators as potential therapeutic tools and the added value of these modulators for treating cancer.
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页数：11
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  • [1] Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation
    Abdoul-Azize, Souleymane
    Dubus, Isabelle
    Vannier, Jean-Pierre
    [J]. ONCOTARGET, 2017, 8 (16) : 27339 - 27352
  • [2] Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation
    Abdullaev, Iskandar F.
    Bisaillon, Jonathan M.
    Potier, Marie
    Gonzalez, Jose C.
    Motiani, Rajender K.
    Trebak, Mohamed
    [J]. CIRCULATION RESEARCH, 2008, 103 (11) : 1289 - U185
  • [3] Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation
    Aki, Anri
    Tanaka, Kento
    Nagaoka, Nobumi
    Kimura, Takako
    Baba, Daichi
    Onodera, Yoshikuni
    Wada, Teiji
    Maeda, Hiroaki
    Nakanishi, Toshiyuki
    Agatsuma, Toshinori
    Komai, Tomoaki
    [J]. FASEB BIOADVANCES, 2020, 2 (08) : 478 - 488
  • [4] Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry
    Albarran, Letizia
    Lopez, Jose J.
    Ben Amor, Nidhal
    Martin-Cano, Francisco E.
    Berna-Erro, Alejandro
    Smani, Tarik
    Salido, Gines M.
    Rosado, Juan A.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [5] Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer
    Arredouani, Mohamed S.
    Lu, Bin
    Bhasin, Manoj
    Eljanne, Miriam
    Yue, Wen
    Mosquera, Juan-Miguel
    Bubley, Glenn J.
    Li, Vivian
    Rubin, Mark A.
    Libermann, Towia A.
    Sanda, Martin G.
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (18) : 5794 - 5802
  • [6] Suppression of Calcium Entry Modulates the Expression of TRβ1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels
    Asghar, Muhammad Yasir
    Knuutinen, Taru
    Holm, Emilia
    Nordstrom, Tommy
    Van Dien Nguyen
    Zhou, You
    Tornquist, Kid
    [J]. CANCERS, 2022, 14 (23)
  • [7] Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
    Asghar, Muhammad Yasir
    Lassila, Taru
    Paatero, Ilkka
    Nguyen, Van Dien
    Kronqvist, Pauliina
    Zhang, Jixi
    Slita, Anna
    Lof, Christoffer
    Zhou, You
    Rosenholm, Jessica
    Tornquist, Kid
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 78 (15) : 5827 - 5846
  • [8] Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation
    Azimi, Iman
    Bong, Alice H.
    Poo, Greta X. H.
    Armitage, Kaela
    Lok, Dawn
    Roberts-Thomson, Sarah J.
    Monteith, Gregory R.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 75 (24) : 4525 - 4537
  • [9] The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    Barretina, Jordi
    Caponigro, Giordano
    Stransky, Nicolas
    Venkatesan, Kavitha
    Margolin, Adam A.
    Kim, Sungjoon
    Wilson, Christopher J.
    Lehar, Joseph
    Kryukov, Gregory V.
    Sonkin, Dmitriy
    Reddy, Anupama
    Liu, Manway
    Murray, Lauren
    Berger, Michael F.
    Monahan, John E.
    Morais, Paula
    Meltzer, Jodi
    Korejwa, Adam
    Jane-Valbuena, Judit
    Mapa, Felipa A.
    Thibault, Joseph
    Bric-Furlong, Eva
    Raman, Pichai
    Shipway, Aaron
    Engels, Ingo H.
    Cheng, Jill
    Yu, Guoying K.
    Yu, Jianjun
    Aspesi, Peter, Jr.
    de Silva, Melanie
    Jagtap, Kalpana
    Jones, Michael D.
    Wang, Li
    Hatton, Charles
    Palescandolo, Emanuele
    Gupta, Supriya
    Mahan, Scott
    Sougnez, Carrie
    Onofrio, Robert C.
    Liefeld, Ted
    MacConaill, Laura
    Winckler, Wendy
    Reich, Michael
    Li, Nanxin
    Mesirov, Jill P.
    Gabriel, Stacey B.
    Getz, Gad
    Ardlie, Kristin
    Chan, Vivien
    Myer, Vic E.
    [J]. NATURE, 2012, 483 (7391) : 603 - 607
  • [10] Regulation of endogenous and heterologous Ca2+ release-activated Ca2+ currents by pH
    Beck, Andreas
    Fleig, Andrea
    Penner, Reinhold
    Peinelt, Christine
    [J]. CELL CALCIUM, 2014, 56 (03) : 235 - 243
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