A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

被引：29

作者：

Liu, Wenming ^{[1
]}

Li, Hengchun ^{[1
,4
]}

Liu, Bo ^{[2
]}

Lv, Tianxing ^{[1
]}

Yang, Chenchen ^{[2
]}

Chen, Si ^{[3
]}

Feng, Liqiang ^{[1
]}

Lai, Liangxue ^{[1
]}

Duan, Ziyuan ^{[1
]}

Chen, Xinwen ^{[3
]}

Li, Pingchao ^{[1
]}

Guan, Suhua ^{[2
]}

Chen, Ling ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Lab Computat Biomed, 190 Kaiyuan Ave, Guangzhou 510530, Peoples R China

[2] Guangzhou nBiomed Ltd, 1 Ruifa Rd, Guangzhou 510535, Peoples R China

[3] Guangzhou Lab, Guangzhou, Peoples R China

[4] Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

EMERGING MICROBES & INFECTIONS | 2023年 / 12卷 / 02期

关键词：

African swine fever virus; adenovirus; infection; mucosal immunity; swine; vaccine; IMMUNITY; CHALLENGE; DELIVERY; PIGS;

D O I：

10.1080/22221751.2023.2233643

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely CP204L (p30), E183L (p54), EP402R (CD2v), B646L (p72), and B602L (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission.

引用

页数：14

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