Quality of Life Longitudinal Evaluation in Prostate Cancer Patients from Radiotherapy Start to 5 Years after IMRT-IGRT

被引：0

作者：

Maggio, Angelo ^{[1
]}

Rancati, Tiziana ^{[2
]}

Gatti, Marco ^{[1
]}

Cante, Domenico ^{[3
]}

Avuzzi, Barbara ^{[2
]}

Bianconi, Cinzia ^{[4
]}

Badenchini, Fabio ^{[2
]}

Farina, Bruno ^{[5
]}

Ferrari, Paolo ^{[6
]}

Giandini, Tommaso ^{[2
]}

Girelli, Giuseppe ^{[5
]}

Landoni, Valeria ^{[7
]}

Magli, Alessandro ^{[8
]}

Moretti, Eugenia ^{[8
]}

Petrucci, Edoardo ^{[3
]}

Salmoiraghi, Paolo ^{[9
]}

Sanguineti, Giuseppe ^{[7
]}

Villa, Elisa ^{[9
]}

Waskiewicz, Justyna Magdalena ^{[6
]}

Guarneri, Alessia ^{[1
]}

Valdagni, Riccardo ^{[2
,10
]}

Fiorino, Claudio ^{[4
]}

Cozzarini, Cesare ^{[4
]}

机构：

[1] IRCCS, Ist Candiolo FPO, I-10060 Candiolo, Italy

[2] Fdn IRCCS Ist Nazl Tumori Milano, I-20133 Milan, Italy

[3] ASL TO4, Osped Ivrea, I-10015 Ivrea, Italy

[4] IRCCS Osped San Raffaele, I-20132 Milan, Italy

[5] Osped Inferm Biella, I-13875 Biella, Italy

[6] Comprensorio Sanit Bolzano, I-39100 Bolzano, Italy

[7] IRCCS Ist Tumori Regina Elena, I-00144 Rome, Italy

[8] Osped Udine, I-33100 Udine, Italy

[9] Clin Gavazzeni Humanitas, I-24121 Bergamo, Italy

[10] Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy

来源：

CURRENT ONCOLOGY | 2024年 / 31卷 / 02期

关键词：

prostate cancer; radiotherapy; EORTCQLQ-C30; questionnaire; quality of life; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; URINARY TOXICITY; IMPACT; SYMPTOMS; SURGERY;

D O I：

10.3390/curroncol31020062

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The purpose of this study is to study the evolution of quality of life (QoL) in the first 5 years following Intensity-modulated radiation therapy (IMRT) for prostate cancer (PCa) and to determine possible associations with clinical/treatment data. Material and methods: Patients were enrolled in a prospective multicentre observational trial in 2010-2014 and treated with conventional (74-80 Gy, 1.8-2 Gy/fr) or moderately hypofractionated IMRT (65-75.2 Gy, 2.2-2.7 Gy/fr). QoL was evaluated by means of EORTC QLQ-C30 at baseline, at radiation therapy (RT) end, and every 6 months up to 5 years after IMRT end. Fourteen QoL dimensions were investigated separately. The longitudinal evaluation of QoL was analysed by means of Analysis of variances (ANOVA) for multiple measures. Results: A total of 391 patients with complete sets of questionnaires across 5 years were available. The longitudinal analysis showed a trend toward the significant worsening of QoL at RT end for global health, physical and role functioning, fatigue, appetite loss, diarrhoea, and pain. QoL worsening was recovered within 6 months from RT end, with the only exception being physical functioning. Based on ANOVA, the most impaired time point was RT end. QoL dimension analysis at this time indicated that acute Grade >= 2 gastrointestinal (GI) toxicity significantly impacted global health, physical and role functioning, fatigue, appetite loss, diarrhoea, and pain. Acute Grade >= 2 genitourinary (GU) toxicity resulted in lower role functioning and higher pain. Prophylactic lymph-nodal irradiation (WPRT) resulted in significantly lower QoL for global health, fatigue, appetite loss, and diarrhoea; lower pain with the use of neoadjuvant/concomitant hormonal therapy; and lower fatigue with the use of an anti-androgen. Conclusions: In this prospective, longitudinal, observational study, high radiation IMRT doses delivered for PCa led to a temporary worsening of QoL, which tended to be completely resolved at six months. Such transient worsening was mostly associated with acute GI/GU toxicity, WPRT, and higher prescription doses.

引用

页码：839 / 848

页数：10

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