Two short approaches to the COVID-19 drug β-<sc>d</sc>-N4-hydroxycytidine and its prodrug molnupiravir

被引：1

作者：

Persaud, Kevin E. ^{[1
]}

Sahu, Rajesh R. ^{[2
]}

Neary, Michelle C. ^{[3
]}

Kapdi, Anant R. ^{[2
]}

Lakshman, Mahesh K. ^{[1
]}

机构：

[1] CUNY City Coll, Dept Chem & Biochem, 160 Convent Ave, New York, NY 10031 USA

[2] Inst Chem Technol, Dept Chem, Nathalal Parekh Rd, Mumbai 400019, India

[3] Hunter Coll, Dept Chem, 695 Pk Ave, New York, NY 10065 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 04期

关键词：

SCALE SYNTHESIS; EIDD-2801; FACILE; NUCLEOSIDE; MK-4482; ROUTE;

D O I：

10.1039/d3ob02039h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molnupiravir, the prodrug for beta-d-N-4-hydroxycytidine (NHC), is marketed by Merck as Lagevrio (TM) against mild-moderate COVID-19, under FDA emergency use authorization. It is the first oral drug against the disease. This work describes two synthetic approaches to NHC and molnupiravir by amide activation in uridine with a peptide-coupling agent and with a 4-chloropyrimidinone nucleoside intermediate.

引用

页码：735 / 740

页数：6

共 51 条

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