Positive association between proinsulin and fatty liver index in people with type 2 diabetes

被引：0
作者：
Nakamura, Akinobu [1 ,2 ]
Miya, Aika [1 ,2 ]
Suzuki, Yuka [1 ,2 ]
Nomoto, Hiroshi [1 ,2 ]
Kameda, Hiraku [1 ,2 ]
Cho, Kyu Yong [1 ,2 ]
Nagai, So [3 ]
Atsumi, Tatsuya [1 ,2 ]
机构：
[1] Hokkaido Univ, Fac Med, Dept Rheumatol Endocrinol & Nephrol, N-15,W-7,Kita Ku, Sapporo 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, N-15,W-7,Kita Ku, Sapporo 0608638, Japan
[3] NTT Sapporo Med Ctr, Dept Med, Div Diabet & Endocrinol, Sapporo 0600061, Japan
来源：
ENDOCRINE JOURNAL | 2024年 / 71卷 / 02期
关键词：
Fatty liver index; Hepatic steatosis; Proinsulin; BETA-CELL DYSFUNCTION; INSULIN;
D O I：
10.1507/endocrj.EJ23-0403
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index group than in the low or moderate groups (all p < 0.01). The moderate fatty liver index group showed higher logarithm-transformed proinsulin than the low group (both p < 0.01). Positive associations between proinsulin and fatty liver index shown in this study would support an involvement of hepato-pancreatic crosstalk in the pathophysiology of type 2 diabetes.
引用
收藏
页码：193 / 197
页数：5
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