Viral and immunologic evaluation of smokers with severe COVID-19

被引：2

作者：

Vecchio, Joseph ^{[1
]}

Regan, James ^{[2
]}

Jiang, Yuting ^{[1
]}

Li, Roy ^{[1
]}

Romain, Hannah ^{[1
]}

Yousuf, Fizah ^{[1
]}

Adel, Thomas ^{[1
]}

Hall, Kevin ^{[1
]}

Dacosta, Jeffrey M. ^{[1
]}

Yu, Xu ^{[3
]}

Li, Jonathan Z. ^{[2
]}

Fofana, Ismael Ben ^{[1
]}

机构：

[1] Boston Coll, Biol Dept, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[3] Harvard Med Sch, MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

CIGARETTE-SMOKING; DISEASE; COHORT; ASSAY; RISK;

D O I：

10.1038/s41598-023-45195-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Smoking negatively affects B cell function and immunoglobulin levels, but it is unclear if this immune dysfunction contributes to the risk of severe COVID-19 in smokers. We evaluated binding IgM, IgA and IgG antibodies to spike and receptor binding domain antigens, and used a pseudovirus assay to quantify neutralization titers in a set of 27 patients with severe COVID-19. We found no significant differences between binding and neutralization antibody responses for people with a smoking history and people who never smoked. High plasma viral load, but not antibody titers, was linked to an increased risk of death. Humoral immune dysfunction was not a major driver of severe COVID-19 in smokers.

引用

页数：10

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