Morphological atypia and molecular profile of Plasmodium vivax: Findings from an outbreak in the Brazilian Amazon

被引：1

作者：

Alves, Amanda Caroline de Jesus ^{[1
,2
]}

dos Santos, Ana Cecilia Feio ^{[1
,2
]}

Peres, Jose Mario Veloso ^{[3
]}

Nascimento, Jose Maria de Souza ^{[3
]}

Barbosa, Danielle Regina Lima ^{[2
]}

Figueiredo, Juliana Vasconcelos ^{[4
]}

Viana, Giselle Maria Rachid ^{[1
,3
]}

Povoa, Marinete Marins ^{[1
,2
]}

机构：

[1] Fed Univ Para, Grad Program Biol Infect & Parasit Agents, Rua Augusto Correa 01, Belem, PA, Brazil

[2] Evandro Chagas Inst, Parasitol Sect, Lab Malaria Entomol, Rodovia BR 316,Km 7, Ananindeua, PA, Brazil

[3] Evandro Chagas Inst, Parasitol Sect, Lab Basic Res Malaria, Rodovia BR 316,Km 7, Ananindeua, PA, Brazil

[4] Fed Rural Univ Amazon, Multiprofess Residency Program Anim Reprod, Ave Presidente Tancredo Neves 2501, Belem, PA, Brazil

来源：

PARASITE | 2023年 / 30卷

关键词：

Plasmodium vivax; Morphological atypia; Genotyping; Outbreak; CIRCUMSPOROZOITE PROTEIN; ANOPHELINE MOSQUITOS; MALARIA; GENOTYPES; VK210; VARIANTS; HUMANS; VK247; BLOOD; FORMS;

D O I：

10.1051/parasite/2023039

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This study aimed to perform morphological and molecular analyses of parasites isolated from the blood of malaria-infected individuals during an outbreak in the Microregion of Cameta, State of Para, Brazilian Amazon. A total of 260 positive samples were identified by microscopy as Plasmodium vivax; however, in three samples, forms considered unusual for the species were found and defined as morphological atypia of P. vivax. Single P. vivax infection was confirmed by qPCR in all samples. Among 256 genotyped samples, the VK247 genotype alone was identified in 255 samples, and the VK210 genotype was found in only one. The study showed that this malaria outbreak was caused by the etiological agent P. vivax, and for the first time, morphological atypia was described in isolates circulating in Brazil. Likewise, for the first time, the VK247 genotype was detected predominantly in single infections in an area of the State of Para, which may suggest a greater circulation of the genotype in the region.

引用

页数：7

共 30 条

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