New role of astrocytes in neuroprotective mechanisms after ischemic stroke

被引：12

作者：

Xie, Xiaoyun ^{[1
]}

Liu, Jingli ^{[1
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Neurol, Nanning, Guangxi, Peoples R China

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2023年 / 81卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Astrocytes; Ischemic Stroke; Neurogenesis; Phagocytosis; Ischemic Preconditioning; Neuroprotective Agents; PRECONDITIONING PROTECTS ASTROCYTES; OXYGEN-GLUCOSE DEPRIVATION; NEURAL STEM-CELLS; REACTIVE ASTROCYTES; GLIAL-CELLS; BRAIN; NEURONS; DEGRADATION; EXPRESSION; RECOVERY;

D O I：

10.1055/s-0043-1770352

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons. However, recent studies have found that astrocytes have more crucial and complex functions in the brain, such as neurogenesis, phagocytosis, and ischemic tolerance. After an ischemic stroke, the activated astrocytes can exert neuroprotective or neurotoxic effects through a variety of pathways. In this review, we will discuss the neuroprotective mechanisms of astrocytes in cerebral ischemia, and mainly focus on reactive astrocytosis or glial scar, neurogenesis, phagocytosis, and cerebral ischemic tolerance, for providing new strategies for the clinical treatment of stroke.

引用

页码：748 / 755

页数：8

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